Parahippocampal deactivation and hyperactivation of central executive, saliency and social cognition networks in autism spectrum disorder

• Author(s): Mouga, Susana ; Duarte, Isabel Catarina ; Café, Cátia ; Sousa, Daniela ; Duque, Frederico ; Oliveira, Guiomar ; Castelo-Branco, Miguel
• Date: 2022
• Persistent ID: https://hdl.handle.net/10316/98760
• Origin: Estudo Geral - Universidade de Coimbra
• Project/scholarship: info:eu-repo/grantAgreement/EC/H2020/777394/EU
• Subject(s): Autism spectrum disorder; Central executive network; Ecological task; Saliency network; Social cognition network; fMRI
• Document Type: Journal article
• Language: English

Description

The concomitant role of the Central Executive, the Saliency and the Social Cognition networks in autism spectrum disorder (ASD) in demanding ecological tasks remains unanswered. We addressed this question using a novel task-based fMRI virtual-reality task mimicking a challenging daily-life chore that may present some difficulties to individuals with ASD: the EcoSupermarketX.

This research was supported by the Portuguese Foundation for Science and Technology: PAC MEDPERSYST POCI-01-0145- FEDER-016428, CONNECT-BCI, POCI-01-0145-FEDER-30852, FCT/UID/4950B/2020, UID- P-4950, DSAIPA/DS/0041/2020, European Commission (AIMS-2-Trials), individual PhD scholarship: SFRH/BD/102779/2014 to SM, CENTRO-01-0145-FEDER-000016 to SM and DS (PI: MCB) and Luso-American Development Foundation (FLAD) Life Sciences.