In vitro activities of kappa-carrageenan isolated from red marine alga Hypnea musciformis: Antimicrobial, anticancer and neuroprotective potential

• Autor(es): Souza, Ricardo Basto ; Frota, Annyta Fernandes ; Silva, Joana ; Alves, Celso ; Neugebauer, Agnieszka Zofia ; Pinteus, Susete ; Rodrigues, José Ariévilo Gurgel ; Cordeiro, Edna Maria Silva ; Almeida, Raimundo Rafael de ; Pedrosa, Rui ; Benevides, Norma Maria Barros
• Data: 2018
• Identificador Persistente: http://hdl.handle.net/10400.8/4993
• Origem: IC-online
• Tipo de Documento: Artigo científico
• Idioma: Inglês
• Contribuidor(es): Repositório IC-Online

Descrição

This study assessed the antioxidant, antimicrobial, anticancer and neuroprotective activities of the kappa(k)-carrageenan isolated from the red alga Hypnea musciformis (Hm-SP). The chemical spectrum of the k-carrageenan fromHm-SPwas confirmed by Fourier transform infrared (FT-IR) spectroscopy.Hm-SP revealed an antibacterial and antifungal action against Staphylococcus aureus and Candida albicans, respectively. Hm-SP did not promoted cytotoxic effects against Human breast cancer (MCF-7) and Human neuroblastoma (SH-SY5Y) cell-lines. However, itwas observed a significant reduction of the cellular proliferation capacity in these cancer cells in presence of the Hm-SP. Furthermore, Hm-SP showed neuroprotective activity in 6-hydroxydopamine-induced neurotoxicity on SH-SY5Y cells by modulation of the mitochondria transmembrane potential and reducing Caspase 3 activity. In addition, Hm-SP demonstrates low antioxidant potential and did not induce significant cytotoxic effects or changes in the cell proliferation on Balb/c 3T3 mouse fibroblast cell-line. In summary, our data suggest that Hm-SP shows antimicrobial, anticancer and neuprotective activities.