Author(s): Catarata, MJ ; Ribeiro, R ; Oliveira, MJ ; Cordeiro, CR ; Medeiros, R
Date: 2020
Persistent ID: https://hdl.handle.net/10216/143500
Origin: Repositório Aberto da Universidade do Porto
Subject(s): Hypoxia; Lung cancer; Renin-angiotensin; Tumor microenvironment
The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supporting a role for the renin-angiotensin system in the lung tumor microenvironment and discusses whether blockade of this pathway in clinical settings may serve as an adjuvant therapy in lung cancer.
