Autor(es): Espinosa-Pereiro, J ; Aguiar, A ; Nara, E ; Medina, A ; Molinas, G ; Tavares, M ; Tortola, T ; Ghimire, S ; Alfenaar, JC ; Sturkenboom, MGG ; Magis-Escurra, C ; Sánchez-Montalva, A ; Barros, H ; Duarte, R
Data: 2025
Identificador Persistente: https://hdl.handle.net/10216/165104
Origem: Repositório Aberto da Universidade do Porto
"Background: Higher than standard doses of rifampicin could improve the treatment outcome of drug-susceptible tuberculosis without compromising the safety of patients. Methods: We performed a systematic review of prospective clinical studies including adults with pulmonary and extrapulmonary TB receiving rifampicin doses above 10mg/kg/day. We extracted the data on overall adverse events (AE), hepatic AE, sputum culture conversion (SCC) at week 8, recurrence, mortality, and pharmacokinetics. We performed a Bayesian network meta-analysis (NMA) using a random-effects model. Results: In 19 studies, 2033 out of 3654 participants received rifampicin doses higher than 10mg/kg/day. The NMA showed an increased risk of overall and hepatic AE for the 40mg/kg/day dose (RR 4.8, 95% CrI 1.1; 25, and 15.00, 95% CrI 1.1; 58.0, respectively), but no other doses, including 50mg/kg/day showed such an increase. Increasing doses improved sputum culture conversion at week 8 (RR 1.3, 95% CrI 1.1; 1.7 for SCC with 35mg/kg/day). Conclusion: Optimal doses of rifampicin may be between 25 and 35mg/kg/day, but should be tailored at the individual or, at least, at the population level."
