Colonisation of the Proximal Intestinal Remnant in Newborn Infants with Enterostomy: a Longitudinal Study Protocol

• Author(s): Barreiros Mota, I ; Marques, C ; Faria, C ; Neto, MT ; Cordeiro-Ferreira, G ; Virella, D ; Pita, A ; Pereira-da-Silva, L ; Calhau, C
• Date: 2019
• Persistent ID: http://hdl.handle.net/10400.17/3453
• Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
• Subject(s): Congenital Malformations; Dysbiosis; Enterostomy; Microbiota; Necrotizing Enterocolitis; Infant, Newborn; HDE CINV; HDE UCI NEO
• Document Type: Journal article
• Language: English
• Contributor(s): Repositório da Unidade Local de Saúde São José

Description

The gut microbiota plays a main role in the maintenance of host's health. Exposure to different conditions in early life contributes to distinct 'pioneer' bacterial communities in the intestine, which shape the newborn infant development. Newborn infants with congenital malformations of the gastrointestinal tract (CMGIT), necrotising enterocolitis (NEC) and spontaneous intestinal perforation (SIP) commonly require abdominal surgery and enterostomy. The knowledge about the colonisation of these newborns' intestine by microorganisms is scarce. This protocol is designed to explore the microbial colonisation over time of the proximal intestinal remnant in newborn infants who underwent surgery for CMGIT, NEC or SIP and require enterostomy.