Autor(es):
Fontes-Carvalho, R ; Marques da Silva, P ; Rodrigues, E ; Araújo, F ; Gavina, C ; Ferreira, J ; Morais, J
Data: 2019
Identificador Persistente: http://hdl.handle.net/10400.17/4221
Origem: Repositório do Centro Hospitalar de Lisboa Central, EPE
Assunto(s): HSM MED; Anticholesteremic Agents / therapeutic use; Cholesterol, LDL / blood*; Cholesterol, LDL / drug effects; Dyslipidemias / blood; Dyslipidemias / drug therapy*; Dyslipidemias / epidemiology; Ezetimibe / therapeutic use*; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*; PCSK9 Inhibitors*; Incidence; Portugal / epidemiology
Descrição
Reducing low-density lipoprotein cholesterol (LDL-C) levels is one of the most important strategies for reducing the risk of cardiovascular events. However, in clinical practice, a high proportion of patients do not achieve recommended LDL-C levels through lifestyle and lipid-lowering therapy with statins and ezetimibe. PCSK9 inhibitors (PCSK9i) are a new therapeutic option that significantly (50-60%) reduces LDL-C levels, which in clinical trials translates into an additional reduction in risk for cardiovascular events, and has a good safety profile. However, it is a high-cost therapy, and therefore its use in clinical practice should take its cost-effectiveness into account. Priority should be given to use in patients at higher cardiovascular risk and those in whom high LDL-C levels persist despite optimal lipid-lowering therapy. This consensus document aims to summarize the main data on the clinical use of PCSK9i and to make recommendations for Portugal on the profile of patients who may benefit most from this therapy.
