Author(s):
Santos, M ; Pinto-Basto, J ; Rio, ME ; Sá, MJ ; Valença, A ; Sá, A ; Dinis, J ; Figueiredo, J ; Bigotte de Almeida, L ; Coelho, I ; Sawcer, S ; Setakis, E ; Compston, A ; Sequeiros, J ; Maciel, P
Date: 2003
Persistent ID: http://hdl.handle.net/10400.23/463
Origin: Repositório Científico do Hospital de Braga
Project/scholarship:
info:eu-repo/grantAgreement/WT///UK;
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F9111%2F2002/PT;
Subject(s): Predisposição Genética para Doença; Testes Genéticos; Esclerose Múltipla
Description
Multiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association. In this study, 6000 microsatellite markers were typed in separately pooled DNA samples from MS patients (n=188) and matched controls (n=188). Interpretable data was obtained from 4661 of these markers. Refining analysis of the most promising markers identified 10 showing potential evidence for association.
