Autor(es): Faleiro, Leonor ; Marques, Ana ; Martins, João ; Jordão, Luísa ; Nogueira, Isabel ; Gumerova, Nadiia I. ; Rompel, Annette ; Aureliano, Manuel
Data: 2022
Identificador Persistente: http://hdl.handle.net/10400.18/8437
Origem: Repositório Científico do Instituto Nacional de Saúde
Assunto(s): Antibacterial Drugs; Bacterial Resistance; Antibiotic Resistance; Wells-Dawson Polyoxometalates; Multiresistant; P5W30; P2W18; Resistência aos Antimicrobianos
Simple Summary: Besides showing the antibacterial activity of the Preyssler-type polyoxotungstate (POT) P5W30 with the ability to affect MRSA cells, we demonstrated that P5W30 also displays other proprieties, such as anti-quorum sensing and antibiofilm. These are biological activities that are reported for a POT for the first time. Quorum sensing and biofilm facilitate the bacterial colonization, antibiotic resistance and persistence in both the environment and host, and its impairment by POTs can greatly contribute to the control of bacterial infections, such as those caused by multiresistant bacteria. Moreover, antiviral activity was also observed using the enterovirus Qβ. NMR stability studies of P5W30 demonstrate that it remains intact, suggesting its responsibility in the described biological activities. Taken together, our results emphasize the potential biomedical use of POTs, particularly the Preyssler-type POT, to fight antibiotic-resistant MRSA strains and their ability to form biofilm, besides being a promising antiviral agent.
