Author(s): Bessa, Maria João ; Brandão, Fátima ; Rosário, Fernanda ; Moreira, Luciana ; Reis, Ana Teresa ; Valdiglesias, Vanessa ; Laffon, Blanca ; Fraga, Sónia ; Teixeira, João Paulo
Date: 2023
Persistent ID: http://hdl.handle.net/10400.18/8666
Origin: Repositório Científico do Instituto Nacional de Saúde
Subject(s): Nanoparticles; Air-liquid Interface; In vitro; Respiratory Models; Submerged Cultures; Toxicity Testing; Toxicologia
Several studies have been conducted to address the potential adverse health risks attributed to exposure to nanoscale materials. While in vivo studies are fundamental for identifying the relation-ship between dose and occurrence of adverse effects, in vitro model systems provide important information regarding the mechanism(s) of action at the molecular level. With a special focus on exposure to inhaled (nano)particulate material toxicity assessment, this review provides an over-view of the available human respiratory models and exposure systems for in vitro testing, advan-tages, limitations, and existing investigations using models of different complexity. A brief overview of the human respiratory system, pathway and fate of inhaled (nano)particles is also presented.
