Autor(es):
Burney, Peter G. ; Potts, James ; Knox-Brown, Ben ; Erhabor, Gregory ; Hacene Cherkaski, Hamid ; Mortimer, Kevin ; Anand, Mahesh Padukudru ; Mannino, David M. ; Cardoso, Joao ; Ahmed, Rana ; Elsony, Asma ; Barbara, Cristina ; Nielsen, Rune ; Bateman, Eric ; Paraguas, Stefanni Nonna ; Cher Loh, Li ; Rashid, Abdul ; Wouters, Emiel F. ; Franssen, Frits M. ; Dias, Hermínia Brites ; Gislason, Thorarinn ; Ghobain, Mohammed A. ; Biaze, Mohammed El ; Agarwal, Dhiraj ; Juvekar, Sanjay ; Rodrigues, Fatima ; Obaseki, Daniel O. ; Koul, Parvaiz A. ; Harrabi, Imed ; Nafees, Asaad A ; Seemungal, Terence ; Janson, Christer ; Vollmer, William M ; Amaral, Andre F. ; Buist, A Sonia
Data: 2025
Identificador Persistente: http://hdl.handle.net/10400.21/18001
Origem: Repositório Científico do Instituto Politécnico de Lisboa
Assunto(s): Pneumology; Airflow obstruction; Forced expiratory volume; Forced vital capacity; Global health; Cross-sectional study
Descrição
Spirometry is used to determine what is "unusual" lung function compared with what is "usual" for healthy non-smokers. This study aimed to investigate regional variation in the forced vital capacity (FVC) and in the forced expiratory volume in one second to FVC ratio (FEV1/FVC) using cross-sectional data from all 41 sites of the multinational Burden of Obstructive Lung Disease study. Participants (5,368 men; 9,649 women), aged ≥40 years, had performed spirometry, had never smoked and reported no respiratory symptoms or diagnoses. To identify regions with similar FVC, we conducted a principal component analysis (PCA) on FVC with age, age2 and height2, separately for men and women. We regressed FVC against age, age2 and height2, and FEV1/FVC against age and height2, for each sex and site, stratified by region. Mean age was 54 years (both sexes), and mean height was 1.69 m (men) and 1.61 m (women). The PCA suggested four regions: 1) Europe and richer countries; 2) the Near East; 3) Africa; and 4) the Far East. For the FVC, there was little variation in the coefficients for age, or age2, but considerable variation in the constant (men: 2.97 L in the Far East to 4.08 L in Europe; women: 2.44 L in the Far East to 3.24 L in Europe) and the coefficient for height2. Regional differences in the constant and coefficients for FEV1/FVC were minimal (<1%). The relation of FVC with age, sex and height varies across and within regions. The same is not true for the FEV1/FVC ratio.
