Autor(es):
Silva, João Carlos ; Ponte, Ana ; Mota, Margarida ; Pinho, Rolando ; Vieira, Nuno ; Oliveira, Rosa ; Mota-Carvalho, Nelson ; Gomes, Ana Catarina ; Afecto, Edgar ; Carvalho, João
Data: 2020
Identificador Persistente: http://hdl.handle.net/10400.14/31815
Origem: Veritati - Repositório Institucional da Universidade Católica Portuguesa
Assunto(s): Fecal microbiota transplantation; Carbapenamase-producing enterobacteriaceae; Multidrug-resistant infections; Decolonization; Intestinal carriage
Descrição
Background and aims: fecal microbiota transplantation (FMT) is effective for recurrent Clostridium difficile infection (CDI). Intestinal decolonization of carbapenamase-producing enterobacteriaceae (CPE) can prevent transmission and infection by these agents. The aim of this study was to assess CPE decolonization after FMT. Methods: this was a case-series study that consecutively included all CPE-carriers that underwent FMT between 2014 and 2019. The indications included refractory/recurrent CDI and CPE-decolonization. Results: out of 21 CPE-carriers, eight were excluded due to incomplete post-FMT testing. CPE decolonization was confirmed in 76.9 % (n = 10). The median decolonization time was 16-weeks (IQR-23) and ranged from two to 53 weeks. Conclusion: FMT may be used in the clinical practice for CPE-decolonization as an alternative to combined antibiotic regimens.
