Autor(es):
Sebastião, Cruz S. ; Cogle, Adis ; Teixeira, Alice D’Alva ; Cândido, Ana Micolo ; Tchoni, Chissengo ; Amorim, Maria João ; Loureiro, N’gueza ; Parimbelli, Paolo ; Penha-Gonçalves, Carlos ; Demengeot, Jocelyne ; Sacomboio, Euclides ; Mendes, Manuela ; Arrais, Margarete ; Morais, Joana ; Vasconcelos, Jocelyne Neto de ; Brito, Miguel
Data: 2022
Identificador Persistente: http://hdl.handle.net/10400.14/39442
Origem: Veritati - Repositório Institucional da Universidade Católica Portuguesa
Assunto(s): Angola; Clinical features; COVID-19; Luanda; SARS-CoV-2
Descrição
Background: Infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with clinical features of diverse severity. Few studies investigated the severity and mortality predictors of coronavirus disease 2019 (COVID-19) in Africa. Herein, we investigated the clinical features of severity and mortality among COVID-19 patients in Luanda, Angola. Methods: This multicenter cohort study involved 101 COVID-19 patients, between December 2020 and April 2021, with clinical and laboratory data collected. Analysis was done using independent-sample t-tests and Chi-square tests. The results were deemed significant when p < 0.05. Results: The mean age of patients was 51 years (ranging from 18 to 80 years) and 60.4% were male. Fever (46%), cough (47%), gastrointestinal symptoms (26.7%), and asthenia (26.7%), were the most common symptoms. About 64.4% of the patients presented coexistent disorders, including hypertension (42%), diabetes (17%), and chronic renal diseases (6%). About 23% were non-severe, 77% were severe, and 10% died during hospitalization. Variations in the concentration of neutrophil, urea, creatinine, c-reactive protein, sodium, creatine kinase, and chloride were independently associated with severity and/or mortality (p < 0.05). Conclusion: Several factors contributed to the severity and mortality among COVID-19 patients in Angola. Further studies related to clinical features should be carried out to help clinical decision-making and follow-up of COVID-19 patients in Angola.
