Author(s): Silva, Maria Joao ; Pinheiro, Ana ; Eusebio, Filomena ; Gaspar, Ana ; de Almeida, Isabel Tavares ; Rivera, Isabel
Date: 2009
Persistent ID: http://hdl.handle.net/10451/21423
Origin: Repositório da Universidade de Lisboa
Subject(s): Pediatrics
The pyruvate dehydrogenase complex (PDHc) is an intramitochondrial multienzyme system, which plays a key role in aerobic glucose metabolism by catalysing the oxidative decarboxylation of pyruvate to acetyl-CoA. Genetic defects in the PDHc lead to lactic a
