Author(s): Pinto, Francisco das Chagas L. ; Uchoa, Daniel Esdras de Andrade ; Silveira, Edilberto Rocha ; Pessoa, Otília Deusdênia Loiola ; Braz-Filho, Raimundo ; Silva, Fernanda Melo e ; Theodoro, Phellipe Norato Estrela Terra ; Espindola, Laila Salmen
Date: 2013
Origin: Oasisbr
Subject(s): Solanum asperum; Antimicóticos; Plantas - compostos bioativos
Two glycoalkaloids: solamargine and solasonine; three flavonoids: tiliroside, 7-O-α-L-ramnopyranosyl-kaempferol and 3-O-[ß-D-glucopyranosyl-(1→6)-α-L-ramnopyranosyl]-7- O-α-L-ramnopyranosyl-kaempferol, in addition to the tripeptide Leu-Ile-Val, the aminoacid proline and the eicosanoic acid were isolated from Solanum asperum (Solanaceae). The structures of all compounds were determined by interpretation of their spectra (IR, MS, 1H and 13C NMR) and comparison with the literature data. All compounds, except the glycoalkaloids, are being reported for the first time for S. asperum. Solasonine showed strong activity (MIC < 0.24 μg/mL) against four filamentous fungi species of the genera Microsporum and Trichophyton.
