Autor(es): Andreani, Tatiana ; De Souza, Ana Luiza R. [UNESP] ; Silva, Amélia M. ; Souto, Eliana B.
Data: 2022
Identificador Persistente: http://hdl.handle.net/11449/220512
Origem: Oasisbr
Assunto(s): Drug delivery; Patent; Silica nanoparticles; Sol-gel
Made available in DSpace on 2022-04-28T19:02:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-10-01
In the recent decades, numerous drug delivery systems based on nanoparticles have been developed. To deliver drugs to a specific site, many vehicles have been designed, including liposomes, lipid and polymeric nanoparticles. However these systems can suffer some limitations such as thermal and physical instability as well as opsonization by reticuloendothelial system. This chapter addresses the development and application of silica gel nanoparticles (nanogels) for drug delivery. The synthesis of nanoparticles by sol-gel technology offers new possibilities and many advantages for embedding organic compounds within silica, controlling their release from the host matrix into a surrounding medium, being a great potential for a variety of drug delivery applications, such as the site-specific delivery and intracellular controlled release of drugs, genes, and other therapeutic agents.
Department of Pharmaceutical Technology Faculty of Health Sciences UFP, Rua Carlos da Maia, 296
Department of Biology and Environment University of Trás-os-Montes e Alto Douro, P.O. Box 1013
Centre for Research and Technology of Agro-Environmental and Biological Sciences University of Trás-os-Montes e Alto Douro (CITAB-UTAD)
Faculty of Pharmaceutical Sciences UNESP
Institute of Biotechnology and Bioengineering Centre of Genomics and Biotechnology University of Trás-os-Montes e Alto Douro (IBB-CGB/UTAD)
Faculty of Pharmaceutical Sciences UNESP
