Autor(es):
Slavov, Svetoslav Nanev ; Bezerra, Rafael dos Santos ; Rodrigues, Evandra Strazza ; Santos, Elaine Vieira ; Borges, Joseane Serrano ; de la Roque, Débora Glenda Lima ; Patané, José Salvatore Leister ; Lima, Alex Ranieri Jerônimo ; Ribeiro, Gabriela ; Viala, Vincent Louis ; de Lima, Loyze Paola Oliveira ; Martins, Antonio Jorge ; dos Santos Barros, Claudia Renata ; Marqueze, Elaine Cristina ; Bernardino, Jardelina de Souza Todão ; Moretti, Debora Botequio ; Brassaloti, Ricardo Augusto ; Cassano, Raquel de Lello Rocha Campos ; Mariani, Pilar Drummond Sampaio Corrêa ; Kitajima, João Paulo ; Santos, Bibiana ; Assato, Patricia Akemi [UNESP] ; da Silva da Costa, Felipe Allan [UNESP] ; Poleti, Mirele Daiana ; Lesbon, Jessika Cristina Chagas ; Mattos, Elisangela Chicaroni ; Banho, Cecilia Artico ; Sacchetto, Lívia ; Moraes, Marília Mazzi ; Grotto, Rejane Maria Tommasini [UNESP] ; Souza-Neto, Jayme A. [UNESP] ; Giovanetti, Marta ; de Alcantara, Luiz Carlos Junior ; Nogueira, Maurício Lacerda ; Fukumasu, Heidge ; Coutinho, Luiz Lehmann ; Calado, Rodrigo Tocantins ; Neto, Raul Machado ; Covas, Dimas Tadeu ; Coccuzzo Sampaio, Sandra ; Elias, Maria Carolina ; Kashima, Simone
Data: 2022
Identificador Persistente: http://hdl.handle.net/11449/222975
Origem: Oasisbr
Assunto(s): Alpha VOC; B.1.1.7; Brazil; Genomic surveillance; SARS-CoV-2; São Paulo
Descrição
Made available in DSpace on 2022-04-28T19:47:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-15
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Financiadora de Estudos e Projetos
The SARS-CoV-2 alpha VOC (also known as lineage B.1.1.7) initially described in the autumn, 2020 in UK, rapidly became the dominant lineage across much of Europe. Despite multiple studies reporting molecular evidence suggestive of its circulation in Brazil, much is still unknown about its genomic diversity in the state of São Paulo, the main Brazilian economic and transportation hub. To get more insight regarding its transmission dynamics into the State we performed phylogenetic analysis on all alpha VOC strains obtained between February and August 2021 from the Sao Paulo state Network for Pandemic Alert of Emerging SARS-CoV-2 variants. The performed phylogenetic analysis showed that most of the alpha VOC genomes were interspersed with viral strains sampled from different Brazilian states and other countries suggesting that multiple independent Alpha VOC introductions from Brazil and overseas have occurred in the São Paulo State over time. Nevertheless, large monophyletic clusters were also observed especially from the Central-West part of the São Paulo State (the city of Bauru) and the metropolitan region of the São Paulo city. Our results highlight the Alpha VOC molecular epidemiology in the São Paulo state and reinforce the need for continued genomic surveillance strategies for the real-time monitoring of potential emerging SARS-CoV-2 variants during the ever-growing vaccination process.
University of São Paulo Ribeirão Preto Medical School Blood Center of Ribeirão Preto
Butantan Institute
University of São Paulo Centro de Genômica Funcional da ESALQ
NGS Soluções Genômicas
Mendelics Análise Genômica SA
São Paulo State University (UNESP) School of Agricultural Sciences Department of Bioprocesses and Biotechnology
Department of Veterinary Medicine School of Animal Science and Food Engineering University of Sao Paulo
Medicine School of São José do Rio Preto (FAMERP) São José do Rio Preto
Molecular Biology Laboratory Applied Biotechnology Laboratory Clinical Hospital of the Botucatu Medical School
Instituto de Ciências Biológicas Universidade Federal de Minas Gerais Belo Horizonte
Instituto Oswaldo Cruz FIOCRUZ Rio de Janeiro
University of São Paulo Ribeirão Preto Medical School
São Paulo State University (UNESP) School of Agricultural Sciences Department of Bioprocesses and Biotechnology
Molecular Biology Laboratory Applied Biotechnology Laboratory Clinical Hospital of the Botucatu Medical School
FAPESP: 2017/26950–6
FAPESP: 2018/15826–5
FAPESP: 2019/08528–0
FAPESP: 2020/10127; 2020/05367–3
Financiadora de Estudos e Projetos: 207.234
