Author(s): Pinheiro, António Mateus ; Pinto, Luísa ; Bessa, J. M. ; Morais, Mónica ; Alves, N. D. ; Monteiro, S. ; Patrício, P. ; Almeida, O. F. X. ; Sousa, Nuno
Date: 2013
Persistent ID: http://hdl.handle.net/1822/24154
Origin: RepositóriUM - Universidade do Minho
Project/scholarship: info:eu-repo/grantAgreement/FCT/5876-PPCDTI/105180/PT ;
Subject(s): Antidepressant; Depression; Gliogenesis; Neurogenesis; Stress; Science & Technology
Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is essential for the maintenance of behavioral homeostasis and that its pharmacological arrest precipitates symptoms commonly found in depressed patients. Further, the incorporation of newly born neurons and astrocytes into the preexisting hippocampal neurocircuitry is shown to be necessary for the spontaneous recovery from the adverse effects of stress and for long-term benefits of AD treatments.
We thank M Carneiro and L Martins for technical assistance. AM-P, LP, MM and SM received fellowships from the Portuguese Foundation for Science and Technology (FCT). This work was supported by FCT (PTDC/SAU-NEU/105180/2008) and the ICVS.
