Author(s): Roque, Susana ; Neves, Margarida Correia ; Mesquita, Ana Raquel Marcelino ; Palha, Joana Almeida ; Sousa, Nuno
Date: 2009
Persistent ID: http://hdl.handle.net/1822/29729
Origin: RepositóriUM - Universidade do Minho
Project/scholarship: info:eu-repo/grantAgreement/FCT/5876-PPCDTI/72699/PT ; info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F24539%2F2005/PT;
An increasing body of evidence implicates proinflammatory cytokines in psychiatric disorders, namely, in depression. Of notice, recent studies showed that anti-inflammatory cytokines, such as IL-10, also modulate depressive-like behavior. In this article, we propose that the anti-inflammatory cytokine IL-10 is a putative link between two of the most widely reported phenomenon observed in depressed patients: the disruption of the hypothalamic-pituitary-adrenal axis and the imbalanced production of cytokines. If so, IL-10 might represent a novel target for antidepressant therapy.
The authors acknowledge the Portuguese Foundation for Science and Technology (FCT) for providing a fellowship to Roque S. (SFRH/BD/24539/2005). This work was supported by a Grant from FCT (PTDC/SAU-NEU/72699/2006).
