Author(s):
Rodrigues, E. ; Silva, Sónia Carina ; Azeredo, Joana ; Henriques, Mariana
Date: 2016
Persistent ID: http://hdl.handle.net/1822/42196
Origin: RepositóriUM - Universidade do Minho
Project/scholarship:
info:eu-repo/grantAgreement/FCT/3599-PPCDT/132966/PT;
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/120495/PT
;
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/119069/PT
;
Subject(s): Antifungal agents; Immunotherapy; Low-level laser therapy; Natural compounds; Photodynamic; Science & Technology
Description
In recent years, there has been a significant increase in the incidence of human fungal infections. The increase in cases of infection caused by Candida species, and the consequent excessive use of antimicrobials, has favored the emergence of resistance to conventional antifungal agents over the past decades. Consequently, Candida infections morbidity and mortality are also increasing. Therefore, new approaches are needed to improve the outcome of patients suffering from Candida infections, because it seems unlikely that the established standard treatments will drastically lower the morbidity of mucocutaneous Candida infections and the high mortality associated with invasive candidiasis. This review aims to present the last advances in the traditional antifungal therapy, and present an overview of novel strategies that are being explored for the treatment of Candida infections, with a special focus on combined antifungal agents, antifungal therapies with alternative compounds (plant extracts and essential oils), adjuvant immunotherapy, photodynamic therapy and laser therapy.
Consolidating Research Expertise and Resources on Cellular and Molecular Biotechnology at CEB/IBB’’, Ref. FCOMP-01-0124-FEDER-027462
BioHealth – Biotechnology and Bioengineering approaches to improve health quality’’, Ref. NORTE-07-0124-FEDER-000027 co-funded by the Programa Operacional Regional do Norte (ON.2 – O Novo Norte), QREN, FEDER.
