Magnetic nanoparticles covered by or entrapped in lipid bilayers: Advances towards dual cancer therapy

• Author(s): Rodrigues, Ana Rita Oliveira ; Almeida, B. G. ; Araújo, João P. ; Queiroz, Maria João R. P. ; Coutinho, Paulo J. G. ; Castanheira, Elisabete M. S.
• Date: 2017
• Persistent ID: https://hdl.handle.net/1822/46117
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Magnetic nanoparticles; Drug delivery; Magnetoliposomes; New antitumor drugs; Dual cancer therapy
• Document Type: Other
• Language: English
• Contributor(s): Universidade do Minho

Description

In this work, both aqueous magnetoliposomes (magnetic nanoparticles entrapped in liposomes) and solid magnetoliposomes (a cluster of particles covered by a lipid bilayer) have been developed, containing either nickel/silica core/shell nanoparticles, nickel ferrite or manganese ferrite nanoparticles, with diameters below 150 nm, suitable for biomedical applications. Moreover, both aqueous (AMLs) and solid (SMLs) magnetoliposomes show a superparamagnetic behavior, the SMLs exhibiting a high saturation magnetization.