Neurodevelopment impact of CO2-pneumoperitoneum in neonates: experimental study in a rat model

• Author(s): Miranda, Alice Augusta Macedo ; Roque, Susana ; Pêgo, José M. ; Correia-Pinto, Jorge
• Date: 2018
• Persistent ID: https://hdl.handle.net/1822/57897
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Animals; Carbon Dioxide; Cytokines; Female; Inflammation; Neurodevelopmental Disorders; Pneumoperitoneum, Artificial; Pregnancy; Rats, Sprague-Dawley; Stress, Physiological; Laparoscopy; Carbon-dioxide pneumoperitoneum; Neurodevelopment; Cytokine; Interleukin
• Document Type: Journal article
• Language: English
• Contributor(s): Universidade do Minho

Description

Laparoscopy is becoming more common in neonates. However, concerns remain about the impact of the carbon-dioxide (CO2)-insufflation over the neonatal brain. We aim to evaluate the peripheral (serum) and central (cerebrospinal fluid [CSF]) cytokine response after neonatal CO2-pneumoperitoneum and its impact over neurodevelopmental milestones acquisition and long-term behavioral outcomes.