Author(s): Gonçalves, Raquel Costa Raínha ; Pinto, Sónia Catarina Silva ; Pina, João ; Gomes-da-Silva, Lígia C. ; Costa, Susana P. G. ; Raposo, M. Manuela M.
Date: 2023
Persistent ID: https://hdl.handle.net/1822/90083
Origin: RepositóriUM - Universidade do Minho
Subject(s): BODIPY derivative; Cancer therapy; Photosensitizers; PDT; Singlet oxygen quantum yield; Synthesis; Heterocycles; Vilsmeier formylation; In vitro assays; Photodynamic therapy
The selectivity of photosensitizers for light activation is a key advantage in photodynamic therapy (PDT), allowing for precise targeting while sparing healthy cells. BODIPY derivatives have emerged as promising PDT candidates due to their tunable photophysical properties and versatile synthesis. Herein, we explore the photophysical characterization and the in vitro photodynamic activity of BODIPY analogues meso-substituted with an anthracene moiety and functionalized with iodine atoms or formyl group at 2,6-position. The formylated anthracene-BODIPY derivative exhibited the highest tumor suppression under irradiation, making it a potential candidate as PDT photosensitizer.
