Author(s):
Liberato,Hortência Ribeiro ; Maciel, Jéssica Bezerra ; Silva, Antônio Wlisses Da ; Bezerra, Maria Eduarda Uchoa ; Brito, Luana San De Oliveira ; Silva, Jacilene ; Ferreira, Maria Kuerislene Amâncio ; Marinho, Marcia Machado ; Marinho, Gabrielle S. ; Pessoa, Otília Deusdênia Loiola ; Guedes, Maria Izabel F. ; Silva, Paulo Goberlânio De Barros ; Gomes, Andreia C ; Menezes, Jane Eire Silva Alencar De ; Santos, Hélcio Silva dos
Date: 2024
Persistent ID: https://hdl.handle.net/1822/91156
Origin: RepositóriUM - Universidade do Minho
Subject(s): Acute toxicity; Anti-inflammatory; Erythroxylum bezerrae; Locomotor behavior; Molecular docking; Neuromodulation of ASICs; Xanthone
Description
The xanthone lichenxanthone did not show toxic effects (LC50>1.0 mg/mL). lichenxanthone prevented nociceptive behavior induced by acidic saline, and its analgesic effect was blocked by amiloride, highlighting the involvement of neuromodulation of acid-sensitive ion channels (ASICs). In the analysis of anti-inflammatory activity, concentrations of 0.1 and 0.5 mg/mL of lichenxanthone reduced the edema induced by k-carrageenan 3.5 %, observed from the fourth hour of analysis. This effect was similar to that observed with ibuprofen (positive control). No leukocyte infiltrates were observed in lichenxanthone, suggesting that the compound acts in the acute inflammatory response. The results of the molecular docking study revealed that lichenxanthone exhibited better affinity energy when compared to the ibuprofen control against the two targets evaluated.
