Author(s): Torres,Karen Cecília de Lima ; Rocha,Natália Pessoa ; Rezende,Vítor Bortolo de ; Dutra,Walderez Ornelas ; Gollob,Kenneth John ; Cardoso,Francisco ; Teixeira,Antonio Lucio
Date: 2016
Origin: Oasisbr
Subject(s): Sydenham chorea; autoimmunity; lymphocytes; B1 cells
The mechanisms involved in the symptoms of Sydenham’s chorea (SC) remain obscure. Taking into account the autoreactive antibody-mediated hypothesis of SC pathogenesis, the persistence of chorea may be associated with increased levels of B1 lymphocytes and other lymphocyte subsets. We evaluated lymphocyte subsets, including B1 and T cells, in patients with remitted (RSC) and persistent (PSC) SC by flow cytometry. Our results showed neither difference in the frequency of T and B lymphocytes subpopulations nor in their activation and functional states. These findings undermine the view of PSC as a sustained cytotoxic cellular-mediated condition. Alternative mechanisms may explain the pathogenesis of PSC.
