Author(s): Cordeiro, Rossana de Aguiar ; Brilhante, Raimunda Sâmia Nogueira ; Rocha, Marcos Fábio Gadelha ; Medrano, Delia Jessica Astete ; Monteiro, André Jalles ; Tavares, Juliane Lira ; Lima, Rita Amanda Chaves de ; Camargo, Zoilo Pires de ; Sidrim, José Júlio Costa
Date: 2013
Origin: Oasisbr
Subject(s): Antifúngicos; Antituberculosos
The aim of the present study was to evaluate the in vitro interactions of antituberculous drugs (ATDs) withantifungalsagainst Coccidioidesposadasii .Eighteendrugcombinations,formedbyanATD(isoniazid, pyrazinamideorethambutol)plusanantifungal(amphotericinB,ketoconazole,itraconazole,fluconazole, voriconazole or caspofungin), were tested using the checkerboard method. All the antimicrobial combi- nations inhibited C. posadasii strains and synergistic interactions were observed for 10 combinations. Antagonism between the tested drugs was not observed. Stronger synergistic interactions were seen in thecombinationsformedbytriazolesplusethambutolaswellasitraconazolepluspyrazinamide.Further studies in animal models are needed to confirm the usefulness of these combinations
