Author(s): Brilhante, Raimunda Sâmia Nogueira ; Fechine, Maria Auxiliadora Bezerra ; Cordeiro, Rossana de Aguiar ; Rocha, Marcos Fa ́bio Gadelha ; Ribeiro, Joyce Fonteles ; Monteiro, André Jalles ; Lima, Rita Amanda Chaves de ; Mesquita, Jaco ́ Ricarte Lima ; Camargo, Zoilo Pires de ; Sidrim, Jóse Júlio Costa
Date: 2013
Origin: Oasisbr
Subject(s): Histoplasma; HIV
This study evaluated the in vitro effect of sulfamethoxazole-trimethoprim against Histoplasma capsulatum var. capsulatum isolated from HIV-positive patients. The drugs were tested by microdilution testing in accordance with the CLSI guidelines. All of the strains were inhibited by sulfamethoxazole-trimethoprim, with MIC ranges of 0.039 (sulfamethoxazole)/0.0078 (trimethoprim) mg/ml to 0.625/0.125 mg/ml for mycelial forms and 0.0025/ 0.0005 to 0.02/0.004 mg/ml for yeast-like forms. However, in vivo studies are necessary to evaluate the significance of these results.
