Author(s): Sousa, Alessandra de Paula Alves , ; Barbosa, Paulo Sergio Ferreira ; Torres, Márcia Rocha ; Martins, Alice Maria Costa ; Martins, René Duarte ; Alves, Renata de Sousa ; Sousa, Daniel Freire de ; Alves, Claudênio Diógenes ; Costa-Lotufo, Letícia Veras ; Monteiro, Helena Serra Azul
Date: 2013
Origin: Oasisbr
Subject(s): Alginatos; Rim
Alginates isolated from Sargassum vulgare , present a strong antitumor activity, associated with kidney reversible damage, as analysed by histopathology of treated animals. In the present study, the renal alteration mechanisms of S. vulgare alginates were investigated using the isolated perfused rat kidney and the isolated perfused rat mesenteric blood vessel methods. The results showed that the effects of Sargassum vulgare low viscosity (SVLV) alginate were more potent than those of Sargassum vulgare high viscosity (SVHV) alginate in the isolated rat kidney. The SVLV alginate caused considerable changes in renal physiology, as shown by an increase in parameters such as perfusion pressure, renal vascular resistance, glomerular filtration rate, urinary flow and sodium, potassium and chloride excretion and by reduction of chloride tubular transport. The effects of SVHV were weaker than those of SVLV. The effects of SVLV on kidney could be related to direct vascular action as demonstrated with SVLV alginate on mesenteric blood vessels. In conclusion, the Sargassum vulgare alginate altered the renal function parameters evaluated. S. vulgare low viscosity alginate renal effects were more potent than S. vulgare high viscosity alginate. It is suggested that physicochemical differences be- tween SVHV and SVLV could explain the differences found in the results. Copyright © 2007 John Wiley & Sons, Ltd.
