Detalhes bibliográficos
| Resumo: | Hypergammaglobulinemia and polyclonal B-cell activation commonly occur in Plasmodium sp. infections. Some of the antibodies produced recognize self-components and are correlated with disease severity in P. falciparum malaria. However, it is not known whether some self-reactive antibodies produced during P. falciparum infection contribute to the events leading to cerebral malaria (CM). We show here a correlation between self-antibody responses to a human brain protein and high levels of circulating TNF alpha (TNFα), with the manifestation of CM in Gabonese children |
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| Autores principais: | Guiyedi, V. |
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| Outros Autores: | Chanseaud, Y.; Fesel, C.; Snounou, G.; Rousselle, J.C.; Lim, P.; Koko, J.; Namane, A.; Cazenave, P.A.; Kombila, M.; Pied, S. |
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| Assunto: | Immunoglobulin G/immunology Malaria, Cerebral/immunology Malaria, Falciparum/immunology Spectrin/immunology |
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| Ano: | 2007 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Repositório do GIMM – Gulbenkian Institute for Molecular Medicine |
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| Idioma: | inglês |
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| Origem: | ARCA |
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