Detalhes bibliográficos
| Resumo: | Dendrimers and dendriplexes, highly branched synthetic macromolecules, have gained popularity as new tools for a variety of nanomedicine strategies due to their unique structure and properties. We show that fluorescent phosphorus dendrimers are well retained by bone marrow-derived macrophages and exhibit robust spectral shift in its emission in response to polar ization conditions. Fluorescence properties of this marker can also assist in identifying macrophage presence and phenotype status at different time points after spinal cord injury. Potential use of a single dendrimer compound as a drug/siRNA carrier and phenotype-specific cell tracer offers new avenues for enhanced cell therapies combined with monitor ing of cell fate and function in spinal cord injury. |
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| Autores principais: | Shakhbazau, Antos |
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| Outros Autores: | Mishra, Manoj; Chu, Tak‐Ho; Brideau, Craig; Cummins, Karen; Tsutsui, Shigeki; Shcharbin, Dzmitry; Majoral, Jean‐Pierre; Mignani, Serge; Blanchard‐Desce, Mireille; Bryszewska, Maria; Yong, V. Wee; Stys, Peter K.; van Minnen, Jan |
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| Assunto: | Macrophage polarization Spinal cord injury Fluorescent phosphorus dendrimer Cell tracker Spectral . Faculdade de Ciências Exatas e da Engenharia |
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| Ano: | 2015 |
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| País: | Portugal |
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| Tipo de documento: | artigo |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Universidade da Madeira |
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| Idioma: | inglês |
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| Origem: | DigitUMa - Repositório da Universidade da Madeira |
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