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Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury

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Resumo:Dendrimers and dendriplexes, highly branched synthetic macromolecules, have gained popularity as new tools for a variety of nanomedicine strategies due to their unique structure and properties. We show that fluorescent phosphorus dendrimers are well retained by bone marrow-derived macrophages and exhibit robust spectral shift in its emission in response to polar ization conditions. Fluorescence properties of this marker can also assist in identifying macrophage presence and phenotype status at different time points after spinal cord injury. Potential use of a single dendrimer compound as a drug/siRNA carrier and phenotype-specific cell tracer offers new avenues for enhanced cell therapies combined with monitor ing of cell fate and function in spinal cord injury.
Autores principais:Shakhbazau, Antos
Outros Autores:Mishra, Manoj; Chu, Tak‐Ho; Brideau, Craig; Cummins, Karen; Tsutsui, Shigeki; Shcharbin, Dzmitry; Majoral, Jean‐Pierre; Mignani, Serge; Blanchard‐Desce, Mireille; Bryszewska, Maria; Yong, V. Wee; Stys, Peter K.; van Minnen, Jan
Assunto:Macrophage polarization Spinal cord injury Fluorescent phosphorus dendrimer Cell tracker Spectral . Faculdade de Ciências Exatas e da Engenharia
Ano:2015
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Universidade da Madeira
Idioma:inglês
Origem:DigitUMa - Repositório da Universidade da Madeira

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