Publicação

Drug resistance and genetic diversity of Mycobacterium tuberculosis in Luanda, Angola: a molecular epidemiological perspective

Ver documento

Detalhes bibliográficos
Resumo:"Sub-saharan Africa contributes heavily to the tuberculosis (TB) burden worldwide. According to the World Health Organization (WHO), Africa exhibits the highest TB regional incidence rate (280 cases per 100 000 habitants) and the highest Human Immunodeficiency Virus co-infection rate (34%), both of which mostly driven by sub-saharan African countries (4). Yet, to this date, Angola has no surveillance data regarding drug resistance and the latest WHO estimates point to the occurrence of 69 000 new cases in 2013 and an incidence rate of 320 cases per 100 000 habitants in the same period (4). Additionally nothing is known regarding the genetic diversity and population structure of circulating Mycobacterium tuberculosis (M. tuberculosis) strains. Its capital city, Luanda, harbours approximately 33.7% of the country’s population and is responsible for one-third of the TB cases nationwide. In the present study, we have addressed the genetic diversity and drug susceptibility profiles of circulating M. tuberculosis strains recovered from patients followed at a central Luanda hospital unit."
Autores principais:Perdigão, João
Outros Autores:Clemente, Sofia; Ramos, Jorge; Masakidi, Pedro; Machado, Diana; Silva, Carla; Couto, Isabel; Viveiros, Miguel; Taveira, Nuno; Portugal, Isabel
Assunto:Mycobacterium tuberculosis Drug resistance Genetic diversity Angola
Ano:2015
País:Portugal
Tipo de documento:documento de conferência
Tipo de acesso:acesso aberto
Instituição associada:Egas Moniz - Cooperativa de Ensino Superior, CRL
Idioma:inglês
Origem:Egas Moniz - Cooperativa de Ensino Superior, CRL
Descrição
Resumo:"Sub-saharan Africa contributes heavily to the tuberculosis (TB) burden worldwide. According to the World Health Organization (WHO), Africa exhibits the highest TB regional incidence rate (280 cases per 100 000 habitants) and the highest Human Immunodeficiency Virus co-infection rate (34%), both of which mostly driven by sub-saharan African countries (4). Yet, to this date, Angola has no surveillance data regarding drug resistance and the latest WHO estimates point to the occurrence of 69 000 new cases in 2013 and an incidence rate of 320 cases per 100 000 habitants in the same period (4). Additionally nothing is known regarding the genetic diversity and population structure of circulating Mycobacterium tuberculosis (M. tuberculosis) strains. Its capital city, Luanda, harbours approximately 33.7% of the country’s population and is responsible for one-third of the TB cases nationwide. In the present study, we have addressed the genetic diversity and drug susceptibility profiles of circulating M. tuberculosis strains recovered from patients followed at a central Luanda hospital unit."