Publication
Internship Reports and Monograph Entitled"Application of Tablets for Effective Oral Delivery of Nanoparticles"
| Summary: | Several types of nanoparticles, including polymeric nanoparticles, liposomes, nanocrystals, and inorganic nanoparticles have been explored as innovative strategies to improve oral drug delivery, enhance bioavailability, and enable more targeted therapeutic effects. To allow their effective administration these nanoparticles must be formulated into dosage forms. Among the available strategies, the development of tablets containing nanoparticles has gained significant interest due to their potential to combine the advantages of nanotechnology with the practicality of conventional oral drug delivery. This review examines different nanoparticles that have been incorporated into tablets, describes their composition, the excipients employed and the different manufacturing processes that have been adopted to incorporate nanoparticles into tablets. Additionally, it is presented a comparison between swallowable and orally disintegrating tablets (ODTs) containing nanoparticles. Particular attention was given to identification of key critical material attributes (CMAs), critical process parameters (CPPs), and critical quality attributes (CQAs) of final dosage forms. The successful development of tablets containing nanoparticles requires ensuring their stability, technological performance, and ultimately their therapeutic efficacy. This review also discusses future perspectives, providing insights into possible innovations and advancements that may guide the next generation of nanoparticle-based tablets. |
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| Main Authors: | Costa, Sara Maria Lopes da |
| Subject: | Tablet Nanoparticle Orally disintegrating tablet Critical quality attribute Manufacturing Comprimido Nanopartícula Comprimido orodispersível Atributo crítico de qualidade Fabricação |
| Year: | 2025 |
| Country: | Portugal |
| Document type: | master thesis |
| Access type: | embargoed access |
| Associated institution: | Universidade de Coimbra |
| Language: | English |
| Origin: | Estudo Geral - Universidade de Coimbra |
| Summary: | Several types of nanoparticles, including polymeric nanoparticles, liposomes, nanocrystals, and inorganic nanoparticles have been explored as innovative strategies to improve oral drug delivery, enhance bioavailability, and enable more targeted therapeutic effects. To allow their effective administration these nanoparticles must be formulated into dosage forms. Among the available strategies, the development of tablets containing nanoparticles has gained significant interest due to their potential to combine the advantages of nanotechnology with the practicality of conventional oral drug delivery. This review examines different nanoparticles that have been incorporated into tablets, describes their composition, the excipients employed and the different manufacturing processes that have been adopted to incorporate nanoparticles into tablets. Additionally, it is presented a comparison between swallowable and orally disintegrating tablets (ODTs) containing nanoparticles. Particular attention was given to identification of key critical material attributes (CMAs), critical process parameters (CPPs), and critical quality attributes (CQAs) of final dosage forms. The successful development of tablets containing nanoparticles requires ensuring their stability, technological performance, and ultimately their therapeutic efficacy. This review also discusses future perspectives, providing insights into possible innovations and advancements that may guide the next generation of nanoparticle-based tablets. |
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