Publicação
Relatórios de Estágio e Monografia intitulada "O Papel da Microbiota Intestinal Infantil nas Alergias Alimentares"
| Resumo: | The human gut is colonised by a set of microorganisms including bacteria, fungi and viruses, which reside in our body, constituting the gut microbiota. Each human being has a unique profile of microorganisms that perform numerous functions essential to human life, acting in the metabolism of nutrients, protection against pathogenic microorganisms, immunomodulation and maintenance of intestinal integrity. Factors such as type of delivery and infant feeding, among others, can influence the establishment of specific microorganisms in the gut microbiota during infancy. Colonisation of the microbiota begins before birth and its development, especially up to the age of three, is of great importance in the growth and maturation of the immune system. However, a perturbation in intestinal homeostasis – dysbiosis – and consequent imbalance in bacterial composition can lead to the development of various pathologies, such as food allergy. Nowadays, food allergy is one of the most prevalent allergic diseases in children. Recent studies have focused on the role of the gut microbiota and its metabolites in the mechanisms underlying food allergy. Although some therapeutic strategies based on microbiota modulation have shown promising in the treatment of food allergy, there is still a long way to go. |
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| Autores principais: | Constantino, Mariana Fonseca |
| Assunto: | Infant gut microbiota Food allergy Dysbiosis Bacterial diversity Health Microbiota intestinal infantil Alergia alimentar Disbiose Diversidade bacteriana Saúde |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Coimbra |
| Idioma: | português |
| Origem: | Estudo Geral - Universidade de Coimbra |
| Resumo: | The human gut is colonised by a set of microorganisms including bacteria, fungi and viruses, which reside in our body, constituting the gut microbiota. Each human being has a unique profile of microorganisms that perform numerous functions essential to human life, acting in the metabolism of nutrients, protection against pathogenic microorganisms, immunomodulation and maintenance of intestinal integrity. Factors such as type of delivery and infant feeding, among others, can influence the establishment of specific microorganisms in the gut microbiota during infancy. Colonisation of the microbiota begins before birth and its development, especially up to the age of three, is of great importance in the growth and maturation of the immune system. However, a perturbation in intestinal homeostasis – dysbiosis – and consequent imbalance in bacterial composition can lead to the development of various pathologies, such as food allergy. Nowadays, food allergy is one of the most prevalent allergic diseases in children. Recent studies have focused on the role of the gut microbiota and its metabolites in the mechanisms underlying food allergy. Although some therapeutic strategies based on microbiota modulation have shown promising in the treatment of food allergy, there is still a long way to go. |
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