Publicação
Doença Autoimune do Ouvido Interno
| Resumo: | Autoimmune Inner Ear Disease (AEID) is defined as a disease responsible for bilateral, asymmetric and progressive sensorineural deafness (over weeks to months), in which several immune mechanisms are involved, such as humoral and cellular responses, expression of cytokines and interstitial adhesion molecules, still little studied and established. In addition to directly affecting the inner ear, the disease can arise due to the deposition of immune complexes, as well as being an integral part of other immune-mediated systemic diseases affecting the inner ear.At a clinical level, the patient, in addition to deafness, may present with vestibular symptoms or symptoms characteristic of other autoimmune diseases. The diagnosis, being a diagnosis of exclusion, is essentially based on the clinic and the response to corticosteroid therapy, the start of which will have to be as early as possible to become effective and eventually reverse the progression of the disease. It should be noted that the audiogram, laboratory tests and imaging tests, such as MRI, can also help, but they still require investigation to be endowed, on their own, with diagnostic value. Other therapies have been studied, such as cytotoxic drugs, biological agents, plasmapheresis, cochlear implants, so far without satisfactory results.Therefore, this work aims to carry out a comprehensive review and clarify the aspects of the disease that deserve clinical investigation, particularly with regard to pathophysiological mechanisms, diagnostic and therapeutic approaches, as well as the main future perspectives. |
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| Autores principais: | Delgado, Ana Margarida Miranda |
| Assunto: | Autoimmune Inner Ear Deafness Sensorineural Corticotherapy Autoimune Ouvido Interno Surdez Neurossensorial Corticoterapia |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso embargado |
| Instituição associada: | Universidade de Coimbra |
| Idioma: | português |
| Origem: | Estudo Geral - Universidade de Coimbra |
| Resumo: | Autoimmune Inner Ear Disease (AEID) is defined as a disease responsible for bilateral, asymmetric and progressive sensorineural deafness (over weeks to months), in which several immune mechanisms are involved, such as humoral and cellular responses, expression of cytokines and interstitial adhesion molecules, still little studied and established. In addition to directly affecting the inner ear, the disease can arise due to the deposition of immune complexes, as well as being an integral part of other immune-mediated systemic diseases affecting the inner ear.At a clinical level, the patient, in addition to deafness, may present with vestibular symptoms or symptoms characteristic of other autoimmune diseases. The diagnosis, being a diagnosis of exclusion, is essentially based on the clinic and the response to corticosteroid therapy, the start of which will have to be as early as possible to become effective and eventually reverse the progression of the disease. It should be noted that the audiogram, laboratory tests and imaging tests, such as MRI, can also help, but they still require investigation to be endowed, on their own, with diagnostic value. Other therapies have been studied, such as cytotoxic drugs, biological agents, plasmapheresis, cochlear implants, so far without satisfactory results.Therefore, this work aims to carry out a comprehensive review and clarify the aspects of the disease that deserve clinical investigation, particularly with regard to pathophysiological mechanisms, diagnostic and therapeutic approaches, as well as the main future perspectives. |
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