Publicação

A Mitochondrial Approach to Cardiovascular Risk and Disease

Detalhes bibliográficos
Resumo:	Cardiovascular diseases (CVDs) are a leading risk factor for mortality worldwide and the number of CVDs victims is predicted to rise through 2030. While several external parameters (genetic, behavioral, environmental and physiological) contribute to cardiovascular morbidity and mortality; intrinsic metabolic and functional determinants such as insulin resistance, hyperglycemia, inflammation, high blood pressure and dyslipidemia are considered to be dominant factors.
Autores principais:	Veloso, Caroline D.
Outros Autores:	Veloso, Caroline; Belew, Getachew D.; Ferreira, Luciana L.; Ferreira, Luciana L.; Grilo, Luís F.; Grilo, Luís F.; Grilo, Luís Filipe Fragoso; CNC - Center for Neuroscience and Cell Biology; CNC - Center for Neuroscience and Cell Biology; Almeida, Luís P. de; Almeida, Luís Pereira de; Almeida, Luís P. de; Almeida, Luís; Almeida, Luís Pereira de; Almeida, Luís; Almeida, L. P.; Almeida, Luís Fernando Morgado Pereira de; GeneT- Centro de Excelência em Terapia Génica em Portugal; CNC - Center for Neuroscience and Cell Biology; CIBB - Center for Innovative Biomedicine and Biotechnology; luispa@ci.uc.pt; luispa@ff.uc.pt; luispa@cnc.uc.pt; lpereiradealmeida@gmail.com; 0000-0001-5831-3307; 5911-1D34-FB6B; A-4605-2009; staff; research; Coimbra; PT; staff; Jones, John Griffith; Jones, John Griffith; Jones, John G.; Jones, John; 0000-0002-3745-3885; B81B-FD5E-E743; staff; Portincasa, Piero; Sardão, Vilma A.; Sardão, Vilma; CNC - Center for Neuroscience and Cell Biology; CNC - Center for Neuroscience and Cell Biology; Almeida, Luís P. de; Almeida, Luís Pereira de; Almeida, Luís P. de; Almeida, Luís; Almeida, Luís Pereira de; Almeida, Luís; Almeida, L. P.; Almeida, Luís Fernando Morgado Pereira de; CIBB - Center for Innovative Biomedicine and Biotechnology; CNC - Center for Neuroscience and Cell Biology; GeneT- Centro de Excelência em Terapia Génica em Portugal; luispa@ci.uc.pt; luispa@ff.uc.pt; luispa@cnc.uc.pt; lpereiradealmeida@gmail.com; 0000-0001-5831-3307; 5911-1D34-FB6B; A-4605-2009; staff; research; Coimbra; PT; 0000-0001-7014-4614; staff; Oliveira, Paulo J.; Oliveira, Paulo J.; Oliveira, Paulo J.; Oliveira, Paulo J.; Oliveira, Paulo; CNC - Center for Neuroscience and Cell Biology; CNC - Center for Neuroscience and Cell Biology; Almeida, Luís P. de; Almeida, Luís Pereira de; Almeida, Luís P. de; Almeida, Luís; Almeida, Luís Pereira de; Almeida, Luís; Almeida, L. P.; Almeida, Luís Fernando Morgado Pereira de; CNC - Center for Neuroscience and Cell Biology; GeneT- Centro de Excelência em Terapia Génica em Portugal; CIBB - Center for Innovative Biomedicine and Biotechnology; luispa@ci.uc.pt; luispa@ff.uc.pt; luispa@cnc.uc.pt; lpereiradealmeida@gmail.com; 0000-0001-5831-3307; 5911-1D34-FB6B; A-4605-2009; staff; research; Coimbra; PT; http://www.cnbc.pt/research/department_group_show.asp?iddep=1138&idgrp=1141\|\|\|; pauloliv@cnc.uc.pt; pauloliv@ci.uc.pt; 0000-0002-5201-9948; 41F-4FB7-5948; H-1980-2011; staff; Paulo J. Oliveira is currently Principal Investigator at the CNC – Center for Neuroscience and Cell Biology, University of Coimbra, Portugal, and Invited Assistant Professor in the same University. He is the current leader of the “Mitochondria, Metabolism and Disease” group (shorturl.at/rsLRZ). He received his Bachelor of Science in Biochemistry from the University de Coimbra in 1999. In 2003, he completed his PhD in Cellular Biology from the same University. After completing his doctorate, Paulo Oliveira spent more than three years working at the Medical School of the University of Minnesota, Duluth, USA, where he collaborated with several researchers and contributed to the publication of several peer-reviewed manuscripts. Paulo Oliveira current research interests focus on mitochondrial biology, investigating the alteration of cardiac mitochondrial function by physical activity and diet, cardiac mitochondrial dysfunction and cell death caused by anti-neoplastic agents, mitochondrial alterations during cancer stem cell differentiation and carcinogenesis or rational designing of mitochondria-directed antioxidants. Paulo has about 260 peer-reviewed publications and a large number of collaborations in Europe, Africa and in the USA. He has also received several prizes from the Portuguese Cardiology Society for his work on cardiac mitochondrial research. Besides research, Paulo Oliveira is often involved in teaching at the Department of Life Sciences, University of Coimbra, as well as in other Universities in Portugal and elsewhere, besides in numerous science communication activities. Of importance, he has maintained a consistent primary role in the organization of national and international scientific meetings, including the International Courses in Toxicology (2005-2010 in Coimbra), Annual Meeting of the European Society for Clinical Investigation (2013, Albufeira, Portugal and 2019, Coimbra, Portugal), the 2014 Meeting of the Portuguese Biochemical Society, and FEBS Advanced Lecture Courses in Oncometabolism (2017, Figueira da Foz, Portugal and 2019 Luso, Portugal). Since May 2019, Paulo Oliveira is also President of the European Society for Clinical Investigation, after being its Vice-President for 2 years. Paulo Oliveira has also been reviewer for more than 40 different scientific journals and over 10 different funding agencies, including the European Commission (Research Executive Agency) and the Portuguese Foundation for Science and Technology. His research group is supported by competitive national and international funding agencies, including the Portuguese Foundation for Science and Technology, the European Commission, and private foundations.
Assunto:	Cardiovascular diseases; Mitochondria; cardiovascular risk; insulin resistance; metabolism; mitochondrial dysfunction.
Ano:	2019
País:	Portugal
Tipo de documento:	artigo
Tipo de acesso:	acesso embargado
Instituição associada:	Universidade de Coimbra
Idioma:	inglês
Origem:	Estudo Geral - Universidade de Coimbra

Descrição
Resumo:	Cardiovascular diseases (CVDs) are a leading risk factor for mortality worldwide and the number of CVDs victims is predicted to rise through 2030. While several external parameters (genetic, behavioral, environmental and physiological) contribute to cardiovascular morbidity and mortality; intrinsic metabolic and functional determinants such as insulin resistance, hyperglycemia, inflammation, high blood pressure and dyslipidemia are considered to be dominant factors.