Publicação
Internship Reports and Monograph entitled "Epigenetic Perspectives in Epilepsy: Innovative Therapeutic Approaches for Disease Management"
| Resumo: | Epilepsy is a complex neurological disorder, characterized by spontaneous recurrent seizures and altered neuronal activity. While there are various antiseizure medications available in the market, a significant number of people with epilepsy struggle to achieve effective seizure control. In recent years, the field of epigenetics has emerged as a promising avenue for understanding the molecular mechanisms underlying epilepsy and developing innovative treatments. Epigenetic modifications, such as DNA methylation, histone modifications, and non-coding RNA molecules, play a crucial role in regulating gene expression and neuronal function.This monograph summarizes the main epigenetic mechanisms in epilepsy and their potential as targets for therapeutic intervention. The impact of DNA methylation and histone modifications on gene expression in epilepsy is explored, along with recent studies investigating the relevance of non-coding RNAs in the development of epilepsy, namely microRNAs. By studying the dynamic interplay between epigenetic modifications and epileptogenesis, valuable insights can be gained into the molecular mechanisms underlying this condition. Furthermore, epigenetic modifications may serve as valuable diagnostic biomarkers, aiding the identification of epilepsy subtypes and predicting treatment response. Lastly, the potential of epigenetic-based therapies, including histone deacetylase inhibitors and DNA methyltransferase inhibitors is discussed. Unravelling the intricate relationship between epigenetic modifications, gene expression, and neuronal excitability may create new opportunities for innovative therapeutic interventions in epilepsy. |
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| Autores principais: | Cardoso, Leonor Costa |
| Assunto: | DNA Methylation Epilepsy Epigenetics Histone modifications Non-coding RNAs ARN Não Codificante Epigenética Epilepsia Metilação do DNA Modificações de histonas |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso embargado |
| Instituição associada: | Universidade de Coimbra |
| Idioma: | inglês |
| Origem: | Estudo Geral - Universidade de Coimbra |
| Resumo: | Epilepsy is a complex neurological disorder, characterized by spontaneous recurrent seizures and altered neuronal activity. While there are various antiseizure medications available in the market, a significant number of people with epilepsy struggle to achieve effective seizure control. In recent years, the field of epigenetics has emerged as a promising avenue for understanding the molecular mechanisms underlying epilepsy and developing innovative treatments. Epigenetic modifications, such as DNA methylation, histone modifications, and non-coding RNA molecules, play a crucial role in regulating gene expression and neuronal function.This monograph summarizes the main epigenetic mechanisms in epilepsy and their potential as targets for therapeutic intervention. The impact of DNA methylation and histone modifications on gene expression in epilepsy is explored, along with recent studies investigating the relevance of non-coding RNAs in the development of epilepsy, namely microRNAs. By studying the dynamic interplay between epigenetic modifications and epileptogenesis, valuable insights can be gained into the molecular mechanisms underlying this condition. Furthermore, epigenetic modifications may serve as valuable diagnostic biomarkers, aiding the identification of epilepsy subtypes and predicting treatment response. Lastly, the potential of epigenetic-based therapies, including histone deacetylase inhibitors and DNA methyltransferase inhibitors is discussed. Unravelling the intricate relationship between epigenetic modifications, gene expression, and neuronal excitability may create new opportunities for innovative therapeutic interventions in epilepsy. |
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