Publicação
Spectroscopic study of aluminum phthalocyanine chloride (AlPcCl) in homogeneous and micro-heterogeneous media consisting of P-123 AND F-127 polymeric micelles
| Resumo: | Aluminum phthalocyanine chloride (AlPcCl) is a photoactive compound which has been used as a photosensitizer (PS) in photodynamic therapy (PDT). Its spectroscopic properties have been studied in solvents of different polarities (ethanol, acetone, dimethylsulfoxide and chloroform). Its solubility has been found to decrease with increasing solvent polarity, together with full self-aggregation in aqueous solution. The binding of AlPcCl to the copolymer PluronicTM micellar class P-123 and F-127 used as solubilizer/carriers was studied. Greater interaction between the more hydrophobic copolymer P-123 and AlPcCl was observed, besides a complex interaction profile involving different AlPcCl forms (self-aggregate/monomeric form) in the copolymers. Time- and temperature-dependent structural organization of AlPcCl in the copolymers was also observed. Thus, AlPcCl has a strong tendency to self-aggregate with increasing solvent polarity, an effect also observed in micellar media. |
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| Autores principais: | Vilsinski, Bruno H. |
| Outros Autores: | Vilsinski, Bruno H.; CQC - Coimbra Chemistry Centre; CQC - Coimbra Chemistry Centre; Fausto, Rui; Fausto, Rui; Fausto, Rui; Lourenço, Rui Fausto Martins Ribeiro da Silva; Fausto, R.; CQC - Coimbra Chemistry Centre; rfausto@ci.uc.pt; 0000-0002-8264-6854; 7004333128; M-9667-2015; staff; Faculty of Sciences and Technology; Faculty of Sciences and Technology; Oliveira, Paulo Eduardo; University of Coimbra; organization; 01-03-1290; Coimbra; Rua Sílvio Lima Univ. Coimbra - Pólo II 3030-790 Coimbra; PT; research; Coimbra; Departamento de Química - Faculdade de Ciências e Tecnologia; PT; 0000-0002-9050-5760; staff; Gerola, Adriana P.; Gerola, Adriana P.; https://orcid.org/0000-0002-4830-7568; exstaff; Lemos, Évelin O.; Barbosa, Patrícia M.; Campanholi, Katieli S. S.; César, Gabriel B.; Tessaro, André L.; Hioka, Noboru; Caetano, Wilker |
| Assunto: | aluminum phthalocyanine chloride polymeric micelles self-aggregation photodynamic therapy |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Coimbra |
| Idioma: | inglês |
| Origem: | Estudo Geral - Universidade de Coimbra |
| Resumo: | Aluminum phthalocyanine chloride (AlPcCl) is a photoactive compound which has been used as a photosensitizer (PS) in photodynamic therapy (PDT). Its spectroscopic properties have been studied in solvents of different polarities (ethanol, acetone, dimethylsulfoxide and chloroform). Its solubility has been found to decrease with increasing solvent polarity, together with full self-aggregation in aqueous solution. The binding of AlPcCl to the copolymer PluronicTM micellar class P-123 and F-127 used as solubilizer/carriers was studied. Greater interaction between the more hydrophobic copolymer P-123 and AlPcCl was observed, besides a complex interaction profile involving different AlPcCl forms (self-aggregate/monomeric form) in the copolymers. Time- and temperature-dependent structural organization of AlPcCl in the copolymers was also observed. Thus, AlPcCl has a strong tendency to self-aggregate with increasing solvent polarity, an effect also observed in micellar media. |
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