Publicação
Tailoring Bioengineered Scaffolds for Regenerative Medicine
| Resumo: | The vision to unravel and develop biological healing mechanisms based on evolving molecular and cellular technologies has led to a worldwide scientific endeavor to establish regenerative medicine. This is a multidisciplinary field that involves basic and preclinical research and development on the repair, replacement, and regrowth or regeneration of cells, tissues, or organs in both diseases (congenital or acquired) and traumas. A total of over 63,000 patients were officially placed on organs’ waiting lists on 31 December 2013 in the European Union (European Commission, 2014). Tissue engineering and regen erative medicine have emerged as promising fields to achieve proper solutions for these concerns. However, we are far from having patient-specific tissue engineering scaffolds that mimic the native tissue regarding both structure and function. The proposed chapter is a qualitative review over the biomaterials, processes, and scaffold designs for tailored bioprinting. Relevant literature on bioengineered scaffolds for regenerative medicine will be updated. It is well known that mechanical properties play significant effects on bio logic behavior which highlight the importance of an extensively discussion on tailoring biomechanical properties for bioengineered scaffolds. The following topics will be dis cussed: scaffold design, biomaterials and scaffolds bioactivity, biofabrication processes, scaffolds biodegradability, and cell viability. Moreover, new insights will be pointed out. |
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| Autores principais: | Amado, Sandra |
| Outros Autores: | Morouço, Pedro; Pascoal-Faria, Paula; Alves, Nuno |
| Assunto: | Regenerative medicine Biomechanics Bioprinting Biomaterials Tailored scaffold |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | capítulo de livro |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Leiria |
| Idioma: | inglês |
| Origem: | IC-online |
| Resumo: | The vision to unravel and develop biological healing mechanisms based on evolving molecular and cellular technologies has led to a worldwide scientific endeavor to establish regenerative medicine. This is a multidisciplinary field that involves basic and preclinical research and development on the repair, replacement, and regrowth or regeneration of cells, tissues, or organs in both diseases (congenital or acquired) and traumas. A total of over 63,000 patients were officially placed on organs’ waiting lists on 31 December 2013 in the European Union (European Commission, 2014). Tissue engineering and regen erative medicine have emerged as promising fields to achieve proper solutions for these concerns. However, we are far from having patient-specific tissue engineering scaffolds that mimic the native tissue regarding both structure and function. The proposed chapter is a qualitative review over the biomaterials, processes, and scaffold designs for tailored bioprinting. Relevant literature on bioengineered scaffolds for regenerative medicine will be updated. It is well known that mechanical properties play significant effects on bio logic behavior which highlight the importance of an extensively discussion on tailoring biomechanical properties for bioengineered scaffolds. The following topics will be dis cussed: scaffold design, biomaterials and scaffolds bioactivity, biofabrication processes, scaffolds biodegradability, and cell viability. Moreover, new insights will be pointed out. |
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