Publicação
Evaluation of new carbon-coating methods for the development of magnetic nanoparticles targeted for biomedical applications
| Resumo: | Nanoscience has recently experienced a strong development, Magnetic Nanoparticles (MNPs) are one of the most attractive nanomaterials. Focusing on the biomedical applications, this thesis has as main objective the development of new carbon coating methods in order to reach the maximum biocompatibility of MNPs upon synthesis. During the research carried out, two different approaches were evaluated to coat a magnetic core composed of magnetite, using phloroglucinol and glyoxal, following the idea of making the process more sustainable and biocompatible. The difference between those approaches resides on the use of PF-127 as porogen agent during the coating step. However, some significant differences were found for the material synthesized without PF-127 as porogen agent, with the most important one being the lack of stabilization in water, a crucial characteristic of MNPs for biomedical applications. This mishap leaded to the continuation of the methodology development with just one material. The material selected was evaluated as nanocarrier to load and deliver drugs using doxorubicin (DOX) and omeprazole (OME). The delivery was tested at different pH values in order to evaluate its influence, as human body has different pH in a normal tissue (pH 7.4) than in the intracellular tumor environment (pH 4.5) or in its surroundings (pH 6.0). |
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| Autores principais: | Magallanes, Nerea Seoane |
| Assunto: | Nanomaterials Magnetic Biomedicine Coating Drug delivery |
| Ano: | 2021 |
| País: | Portugal |
| Tipo de documento: | dissertação de mestrado |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| Resumo: | Nanoscience has recently experienced a strong development, Magnetic Nanoparticles (MNPs) are one of the most attractive nanomaterials. Focusing on the biomedical applications, this thesis has as main objective the development of new carbon coating methods in order to reach the maximum biocompatibility of MNPs upon synthesis. During the research carried out, two different approaches were evaluated to coat a magnetic core composed of magnetite, using phloroglucinol and glyoxal, following the idea of making the process more sustainable and biocompatible. The difference between those approaches resides on the use of PF-127 as porogen agent during the coating step. However, some significant differences were found for the material synthesized without PF-127 as porogen agent, with the most important one being the lack of stabilization in water, a crucial characteristic of MNPs for biomedical applications. This mishap leaded to the continuation of the methodology development with just one material. The material selected was evaluated as nanocarrier to load and deliver drugs using doxorubicin (DOX) and omeprazole (OME). The delivery was tested at different pH values in order to evaluate its influence, as human body has different pH in a normal tissue (pH 7.4) than in the intracellular tumor environment (pH 4.5) or in its surroundings (pH 6.0). |
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