Publicação
In vitro growth inhibitory activity of the Portuguese wild mushroom Clitocybe alexandri in human tumour cell lines
| Resumo: | Some mushrooms are a powerful source of bioactive compounds. lndeed, many pre-clinical studies have been conducted in human tumour cell lines and in some cases a number of compounds extracted from mushrooms have entered clinical trials [1]. Our previous results showed that phenolic (methanolic and ethanolic) and polissacharidic extracts from Clitocybe alexandri inhibited the growth of four human cell lines (lung, breast, colon and gastric cancer) [2]. The aim of the present work was to: i) further elucidate the mechanism of action of the ethanolic extract that leads to the observed cell growth inhibition, by analysing the cell cycle profile of the NCI-H460 cells treated with this extract and ii) identify and quantify the chemical compounds present in the phenolic and polissacharidic extracts. |
|---|---|
| Autores principais: | Vaz, Josiana A. |
| Outros Autores: | Almeida, Gabriela M.; Martins, Anabela; Vasconcelos, M. Helena; Ferreira, Isabel C.F.R. |
| Ano: | 2010 |
| País: | Portugal |
| Tipo de documento: | documento de conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| Resumo: | Some mushrooms are a powerful source of bioactive compounds. lndeed, many pre-clinical studies have been conducted in human tumour cell lines and in some cases a number of compounds extracted from mushrooms have entered clinical trials [1]. Our previous results showed that phenolic (methanolic and ethanolic) and polissacharidic extracts from Clitocybe alexandri inhibited the growth of four human cell lines (lung, breast, colon and gastric cancer) [2]. The aim of the present work was to: i) further elucidate the mechanism of action of the ethanolic extract that leads to the observed cell growth inhibition, by analysing the cell cycle profile of the NCI-H460 cells treated with this extract and ii) identify and quantify the chemical compounds present in the phenolic and polissacharidic extracts. |
|---|