Publicação
Chiral separation of nadolol stereoisomers by liquid chromatography : screening of mobile phase composition and SMB separation
| Resumo: | This work describes a systematic approach to rapid development of simulated moving bed (SMB) chiral chromatographic separations. The presented methodology involves several pulse experiments using a single-column to screen the best mobile phase composition using a Chiralpak AD stationary phase and equilibrium adsorption data used to specify the initial flow rates of the SMB operation. |
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| Autores principais: | Ribeiro, António E. |
| Outros Autores: | Pais, Luís S.; Rodrigues, Alírio |
| Assunto: | Nadolol Chiral separation Mobile phase composition Simulated moving red |
| Ano: | 2012 |
| País: | Portugal |
| Tipo de documento: | documento de conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| Resumo: | This work describes a systematic approach to rapid development of simulated moving bed (SMB) chiral chromatographic separations. The presented methodology involves several pulse experiments using a single-column to screen the best mobile phase composition using a Chiralpak AD stationary phase and equilibrium adsorption data used to specify the initial flow rates of the SMB operation. |
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