Publicação
Coprinopsis atramentaria extract, organic acids and synthesized methylated derivatives as antibacterial and antifungal agents
| Resumo: | Mushrooms have been studied for their antimicrobial activity and revealed promising results against pathogenic bacteria and fungi. Coprinopsis atramentaria (Bull.: Fr.) Redhead, Vilgalys&Moncalvo, is a wild edible mushroom previously characterized by us for its nutritional composition, and the methanolic extract showed antioxidant and antitumor activities p-Hydroxybenzoic(HA) (4.71 mg/100 g dry weight), p-coumaric (CoA) (0.82 mg/100 g) and cinnamic (CA) (1.70 mg/100 g) acids were identified in the mentioned extract. Methylated derivatives of these identified organic acids were synthesized in order to obtain a complete series of methylated derivatives of each organic acid. The antimicrobial and demelanizing activities of C. atramentaria extract, identified organic acids and synthesized methylated derivatives were evaluated and compared. The antifungal activity was stronger than the antibacterial effects. The individual compounds (mostly organic acids) gave higher activity than the extract and even higher than the standards used in the assays. Methylated derivatives presented the highest demelanizing activity towards Aspergillus niger, A. fumigatus and Penicillium verrucosum var. cyclopium. The inclusion of methyl groups in the parental compound CoA strongly increased its antibacterial and antifungal activities, while in the case of HA and CAthe inclusion of methyl groups increased the demelanizing activity, but decreased the antimicrobial properties. The present work contributes to the knowledge of the mechanisms involved in the antimicrobial properties of organic acids usually present in mushrooms and that suffer metabolism, namely methylation reactions. Organic acids and methylated derivatives could be used as antimicrobial agents. |
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| Autores principais: | Heleno, Sandrina A. |
| Outros Autores: | Ferreira, Isabel C.F.R.; Ćirić, Ana; Glamočlija, Jasmina; Martins, Anabela; Queiroz, Maria João R.P.; Soković, Marina |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | documento de conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| Resumo: | Mushrooms have been studied for their antimicrobial activity and revealed promising results against pathogenic bacteria and fungi. Coprinopsis atramentaria (Bull.: Fr.) Redhead, Vilgalys&Moncalvo, is a wild edible mushroom previously characterized by us for its nutritional composition, and the methanolic extract showed antioxidant and antitumor activities p-Hydroxybenzoic(HA) (4.71 mg/100 g dry weight), p-coumaric (CoA) (0.82 mg/100 g) and cinnamic (CA) (1.70 mg/100 g) acids were identified in the mentioned extract. Methylated derivatives of these identified organic acids were synthesized in order to obtain a complete series of methylated derivatives of each organic acid. The antimicrobial and demelanizing activities of C. atramentaria extract, identified organic acids and synthesized methylated derivatives were evaluated and compared. The antifungal activity was stronger than the antibacterial effects. The individual compounds (mostly organic acids) gave higher activity than the extract and even higher than the standards used in the assays. Methylated derivatives presented the highest demelanizing activity towards Aspergillus niger, A. fumigatus and Penicillium verrucosum var. cyclopium. The inclusion of methyl groups in the parental compound CoA strongly increased its antibacterial and antifungal activities, while in the case of HA and CAthe inclusion of methyl groups increased the demelanizing activity, but decreased the antimicrobial properties. The present work contributes to the knowledge of the mechanisms involved in the antimicrobial properties of organic acids usually present in mushrooms and that suffer metabolism, namely methylation reactions. Organic acids and methylated derivatives could be used as antimicrobial agents. |
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