Publicação
Design, synthesis and preliminar antioxidant evaluation of new hydroxy- chromone and xanthone derivatives
| Resumo: | Chromone and xanthone derivativas are well-known for their outstanding antioxidant properties. ln an effort to develop new antioxidants with improved efficacy, here we cteveloped a new synthetic strategy to prepare hydroxylated chromones 3 and xanthones 4 with extended conjugated rr-systems. The synthetic strategy involved the aldolcondensation of 2-methylchromones 1 with cinnamaldehyde 2 to give chromones 3. Subsequent electrocyclization and oxidation of chromones 3 afforded xanthones 4 (Fig. 1 ). The scavenging activities of both derivativas 3 and 4 were addressed against both reactive oxygen species (ROS) and reactive nitrogen species (RNS). Ali tested compounds exhibited scavenger effects dependent on the concentration, with ICso values found in the micromolar range [1]. |
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| Autores principais: | Albuquerque, Hélio |
| Outros Autores: | Proença, Carina; Ribeiro, Daniela; Freitas, Marisa; Santos, Clementina M.M.; Fernandes, Eduarda; Silva, Artur |
| Assunto: | Antioxidant Hydroxychromone Xanthone derivativas |
| Ano: | 2018 |
| País: | Portugal |
| Tipo de documento: | documento de conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| Resumo: | Chromone and xanthone derivativas are well-known for their outstanding antioxidant properties. ln an effort to develop new antioxidants with improved efficacy, here we cteveloped a new synthetic strategy to prepare hydroxylated chromones 3 and xanthones 4 with extended conjugated rr-systems. The synthetic strategy involved the aldolcondensation of 2-methylchromones 1 with cinnamaldehyde 2 to give chromones 3. Subsequent electrocyclization and oxidation of chromones 3 afforded xanthones 4 (Fig. 1 ). The scavenging activities of both derivativas 3 and 4 were addressed against both reactive oxygen species (ROS) and reactive nitrogen species (RNS). Ali tested compounds exhibited scavenger effects dependent on the concentration, with ICso values found in the micromolar range [1]. |
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