Publicação
Enhancing trans-resveratrol topical delivery and photostability through entrapment in chitosan/gum Arabic Pickering emulsions
| Resumo: | The surfactant-free nature and higher stability of Pickering emulsions make them preferable solutions over conventional emulsions for skin applications. In this work, Pickering emulsions stabilized by chitosan/gum Arabic (CH/GA) nanoparticles were tested as vehicles for trans-resveratrol topical delivery. Skin absorption was examined ex vivo using Franz diffusion cells and porcine skin. Pickering emulsions allowed higher cutaneous retention and lower permeation of resveratrol, in comparison with a control solution based on a 20% v/v ethanol. The total amount of resveratrol retained in the skin, 24 h after the application, was 11.60% and 10.82% of the applied dose for the tested Pickering emulsion-based formulations prepared with 0.5% and 1.5%w/v CH/GA nanoparticles, respectively. In contrast, resveratrol skin retention from the control solution was only 2.86%. Confocal laser scanning microscopy revealed enhanced skin deposition of Nile Red to deeper layers from the Pickering emulsionbased formulations. Moreover, Pickering emulsions led to trans-resveratrol photostability increase, as measured after exposure to UV for 4 h. These results show that the CH/GA Pickering emulsions are promising solutions for the topical delivery of trans-resveratrol and have the potential to be used as green cosmetic products. |
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| Autores principais: | Sharkawy, Asma |
| Outros Autores: | Casimiro, Filipa M.; Barreiro, M.F.; Rodrigues, Alírio |
| Assunto: | Biodegradable Chitosan/gum Arabic nanoparticles Photostability Pickering emulsions Resveratrol Topical delivery |
| Ano: | 2020 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| Resumo: | The surfactant-free nature and higher stability of Pickering emulsions make them preferable solutions over conventional emulsions for skin applications. In this work, Pickering emulsions stabilized by chitosan/gum Arabic (CH/GA) nanoparticles were tested as vehicles for trans-resveratrol topical delivery. Skin absorption was examined ex vivo using Franz diffusion cells and porcine skin. Pickering emulsions allowed higher cutaneous retention and lower permeation of resveratrol, in comparison with a control solution based on a 20% v/v ethanol. The total amount of resveratrol retained in the skin, 24 h after the application, was 11.60% and 10.82% of the applied dose for the tested Pickering emulsion-based formulations prepared with 0.5% and 1.5%w/v CH/GA nanoparticles, respectively. In contrast, resveratrol skin retention from the control solution was only 2.86%. Confocal laser scanning microscopy revealed enhanced skin deposition of Nile Red to deeper layers from the Pickering emulsionbased formulations. Moreover, Pickering emulsions led to trans-resveratrol photostability increase, as measured after exposure to UV for 4 h. These results show that the CH/GA Pickering emulsions are promising solutions for the topical delivery of trans-resveratrol and have the potential to be used as green cosmetic products. |
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