Publicação
Epoxidation of 2-Styrylchromone derivatives
| Resumo: | 2-Styrylchromones constitute a small group of natural heterocyclic compounds with significant biological properties. Certain natural and synthetic hydroxyl derivatives have shown important pharmacological and mainly antioxidant activities [1 ,2]. We are interested in the design of new 2-styrylchromones analogues containing hydroxyl groups at C-3 and in the Ca=C~ systems because they could increase the antioxidation activity of these type of compounds [2]. Our first approach is the preparation of epoxy systems and then we will try to open the epoxy ring to give the desired hydroxyl derivatives. We studied the epoxidation of 2-styryl-chromones 1 with hydrogen peroxide and iodosylbenzene using [salen Mn(lll)] as catalyst, and the epoxy products 2 were obtained in moderate yields. Since the best results were obtained with iodosylbenzene, we applied oxidant to compounds 3 in order to prepare 4. In this communication, we will report the synthetic details and the structural characterisation of the epoxides 3 and 4. |
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| Autores principais: | Santos, Clementina M.M. |
| Outros Autores: | Silva, Artur; Cavaleiro, José; Patonay, Támas; Lévai, Albert |
| Ano: | 2004 |
| País: | Portugal |
| Tipo de documento: | documento de conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| Resumo: | 2-Styrylchromones constitute a small group of natural heterocyclic compounds with significant biological properties. Certain natural and synthetic hydroxyl derivatives have shown important pharmacological and mainly antioxidant activities [1 ,2]. We are interested in the design of new 2-styrylchromones analogues containing hydroxyl groups at C-3 and in the Ca=C~ systems because they could increase the antioxidation activity of these type of compounds [2]. Our first approach is the preparation of epoxy systems and then we will try to open the epoxy ring to give the desired hydroxyl derivatives. We studied the epoxidation of 2-styryl-chromones 1 with hydrogen peroxide and iodosylbenzene using [salen Mn(lll)] as catalyst, and the epoxy products 2 were obtained in moderate yields. Since the best results were obtained with iodosylbenzene, we applied oxidant to compounds 3 in order to prepare 4. In this communication, we will report the synthetic details and the structural characterisation of the epoxides 3 and 4. |
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