Publicação
Bilirubin levels and redox status in a young healthy population
| Resumo: | The additional TA repeat (c.-41_ -40dupTA) in the promoter of the uridine diphosphate glucuronosyltransferase (UGT1A1) gene is associated with a decrease in gene transcription, a decline in bilirubin conjugation and, therefore, with an increase in circulating unconjugated bilirubin (UCB) [1] . The TA repeat polymorphism is remarkably prevalent in the Caucasian white population and is the main cause of Gilbert’s syndrome [1] . Bilirubin, the key metabolic product of hemoglobin (Hb) catabolism, has antioxidant properties that seem to have a protective effect in oxidative stress conditions, such as in atherosclerosis, coronary heart disease, inflammation, and cancer [2] . Some studies showed that high levels of bilirubin can be toxic to neurons in newborn infants. |
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| Autores principais: | Rodrigues, Carina |
| Outros Autores: | Rocha, Susana; Nascimento, Henrique; Vieira, Emília; Santos, Rosário; Santos-Silva, Alice; Costa, Elísio; Bronze-da-Rocha, Elsa |
| Assunto: | Bilirubin Redox status |
| Ano: | 2013 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| Resumo: | The additional TA repeat (c.-41_ -40dupTA) in the promoter of the uridine diphosphate glucuronosyltransferase (UGT1A1) gene is associated with a decrease in gene transcription, a decline in bilirubin conjugation and, therefore, with an increase in circulating unconjugated bilirubin (UCB) [1] . The TA repeat polymorphism is remarkably prevalent in the Caucasian white population and is the main cause of Gilbert’s syndrome [1] . Bilirubin, the key metabolic product of hemoglobin (Hb) catabolism, has antioxidant properties that seem to have a protective effect in oxidative stress conditions, such as in atherosclerosis, coronary heart disease, inflammation, and cancer [2] . Some studies showed that high levels of bilirubin can be toxic to neurons in newborn infants. |
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