Detalhes bibliográficos
| Resumo: | In microcirculation the cell-free layer is believed to reduce the friction between red blood cells (RBCs) and endothelial cells and consequently reduce blood flow resistance. However, the complex formation of the cell-free layer has not yet been convincingly described mainly due to multi-physical and hemorheological factors that affect this phenomenon. In this experimental work, we study the effect of hematocrit (Hct) on the thickness of the cell-free layer in straight circular polydimethylsiloxane (PDMS) microchannels. The channels studied are 73 ± 2 mm in diameter, flexible and circular to mimic blood vessels. The images are captured using confocal microscopy and are post-processed using Image J and MATLAB. The formation of a cell-free layer is clearly visible in the images captured and by using a combination of image analysis techniques we are able to detect an increase in the cell-free layer thickness as Hct decreases. |
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| Autores principais: | Cerdeira, Tânia Filipa Alves |
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| Outros Autores: | Lima, Rui A.; Oliveira, Mónica; Monteiro, Fernando C.; Ishikawa, Takuji; Imai, Yohsuke; Yamaguchi, Takami |
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| Assunto: | Cell-free layer Microchannels |
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| Ano: | 2010 |
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| País: | Portugal |
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| Tipo de documento: | comunicação em conferência |
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| Tipo de acesso: | acesso aberto |
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| Instituição associada: | Instituto Politécnico de Bragança |
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| Idioma: | inglês |
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| Origem: | Biblioteca Digital do IPB |
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