Publicação
Individual motions of red blood cells in high-hematocrit blood flowing in a microchannel with complex geometries
| Resumo: | Blood flow in a microchannel with complex geometries has been investigated to develop biomedical microdevices (e.g. Faivre et al., 2006) or to understand pathology in small vessels, such as lacunar infarcts. In a small channel, say 100 μm in diameter, the blood is no longer assumed to be a homogeneous fluid because the size of the red blood cells (RBCs) cannot be neglected compared to the generated flow field (the diameter of a RBC is about 8 μm). In such a case, we must treat the blood as a multiphase fluid, and investigate the motion of individual cells in discussing the flow field. In this study, we investigated the motion of RBCs in a microchannel with stenosis or bifurcation using a confocal micro-PTV system. We measured individual trajectories of RBCs under high Hct conditions (up to 20%), when the interactions between RBCs become significant. We discuss the effect of Hct on the flow field and cell-free layers, as well as the effect of deformability of RBCs on the cell-free layer thickness by hardening RBCs using a glutaraldehyde treatment. |
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| Autores principais: | Ishikawa, Takuji |
| Outros Autores: | Fujiwara, Hiroki; Matsuki, Noriaki; Lima, Rui A.; Imai, Yohsuke; Ueno, H.; Yamaguchi, Takami |
| Assunto: | Red blood cell Microcirculation |
| Ano: | 2009 |
| País: | Portugal |
| Tipo de documento: | comunicação em conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| Resumo: | Blood flow in a microchannel with complex geometries has been investigated to develop biomedical microdevices (e.g. Faivre et al., 2006) or to understand pathology in small vessels, such as lacunar infarcts. In a small channel, say 100 μm in diameter, the blood is no longer assumed to be a homogeneous fluid because the size of the red blood cells (RBCs) cannot be neglected compared to the generated flow field (the diameter of a RBC is about 8 μm). In such a case, we must treat the blood as a multiphase fluid, and investigate the motion of individual cells in discussing the flow field. In this study, we investigated the motion of RBCs in a microchannel with stenosis or bifurcation using a confocal micro-PTV system. We measured individual trajectories of RBCs under high Hct conditions (up to 20%), when the interactions between RBCs become significant. We discuss the effect of Hct on the flow field and cell-free layers, as well as the effect of deformability of RBCs on the cell-free layer thickness by hardening RBCs using a glutaraldehyde treatment. |
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