Publicação
Individual motions of red blood cells in high-hematocrit blood flowing in a microchannel with complex geometries
| Resumo: | Blood flow in a microchannel with complex geometries has been investigated to develop biomedical microdevices (e.g. Faivre et al., 2006) or to understand pathology in small vessels, such as lacunar infarcts. In a small channel, say 100 μm in diameter, the blood is no longer assumed to be a homogeneous fluid because the size of the red blood cells (RBCs) cannot be neglected compared to the generated flow field (the diameter of a RBC is about 8 μm). In such a case, we must treat the blood as a multiphase fluid, and investigate the motion of individual cells in discussing the flow field. In this study, we investigated the motion of RBCs in a microchannel with stenosis or bifurcation using a confocal micro-PTV system. We measured individual trajectories of RBCs under high Hct conditions (up to 20%), when the interactions between RBCs become significant. We discuss the effect of Hct on the flow field and cell-free layers, as well as the effect of deformability of RBCs on the cell-free layer thickness by hardening RBCs using a glutaraldehyde treatment. |
|---|---|
| Autores principais: | Ishikawa, Takuji |
| Outros Autores: | Fujiwara, Hiroki; Matsuki, Noriaki; Lima, Rui A.; Imai, Yohsuke; Ueno, H.; Yamaguchi, Takami |
| Assunto: | Red blood cell Microcirculation |
| Ano: | 2009 |
| País: | Portugal |
| Tipo de documento: | comunicação em conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital do IPB |
| _version_ | 1863850921964863488 |
|---|---|
| author | Ishikawa, Takuji |
| author2 | Fujiwara, Hiroki Matsuki, Noriaki Lima, Rui A. Imai, Yohsuke Ueno, H. Yamaguchi, Takami |
| author2_role | author author author author author author |
| author_facet | Ishikawa, Takuji Fujiwara, Hiroki Matsuki, Noriaki Lima, Rui A. Imai, Yohsuke Ueno, H. Yamaguchi, Takami |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital do IPB |
| country_str | PT |
| creators_json_str | [{\"Person.name\":\"Ishikawa, Takuji\"},{\"Person.name\":\"Fujiwara, Hiroki\"},{\"Person.name\":\"Matsuki, Noriaki\"},{\"Person.name\":\"Lima, Rui A.\",\"Person.identifier.orcid\":\"0000-0003-3428-637X\"},{\"Person.name\":\"Imai, Yohsuke\"},{\"Person.name\":\"Ueno, H.\"},{\"Person.name\":\"Yamaguchi, Takami\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital do IPB |
| datacite.creators.creator.creatorName.fl_str_mv | Ishikawa, Takuji Fujiwara, Hiroki Matsuki, Noriaki Lima, Rui A. Imai, Yohsuke Ueno, H. Yamaguchi, Takami |
| datacite.date.Accepted.fl_str_mv | 2009-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2010-01-27T20:11:23Z |
| datacite.date.embargoed.fl_str_mv | 2010-01-27T20:11:23Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Red blood cell Microcirculation |
| datacite.titles.title.fl_str_mv | Individual motions of red blood cells in high-hematocrit blood flowing in a microchannel with complex geometries |
| dc.contributor.none.fl_str_mv | Biblioteca Digital do IPB |
| dc.creator.none.fl_str_mv | Ishikawa, Takuji Fujiwara, Hiroki Matsuki, Noriaki Lima, Rui A. Imai, Yohsuke Ueno, H. Yamaguchi, Takami |
| dc.date.Accepted.fl_str_mv | 2009-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2010-01-27T20:11:23Z |
| dc.date.embargoed.fl_str_mv | 2010-01-27T20:11:23Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/1553 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | ASME |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Red blood cell Microcirculation |
| dc.title.fl_str_mv | Individual motions of red blood cells in high-hematocrit blood flowing in a microchannel with complex geometries |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_5794 |
| description | Blood flow in a microchannel with complex geometries has been investigated to develop biomedical microdevices (e.g. Faivre et al., 2006) or to understand pathology in small vessels, such as lacunar infarcts. In a small channel, say 100 μm in diameter, the blood is no longer assumed to be a homogeneous fluid because the size of the red blood cells (RBCs) cannot be neglected compared to the generated flow field (the diameter of a RBC is about 8 μm). In such a case, we must treat the blood as a multiphase fluid, and investigate the motion of individual cells in discussing the flow field. In this study, we investigated the motion of RBCs in a microchannel with stenosis or bifurcation using a confocal micro-PTV system. We measured individual trajectories of RBCs under high Hct conditions (up to 20%), when the interactions between RBCs become significant. We discuss the effect of Hct on the flow field and cell-free layers, as well as the effect of deformability of RBCs on the cell-free layer thickness by hardening RBCs using a glutaraldehyde treatment. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | conferencePaper |
| fulltext.url.fl_str_mv | https://bibliotecadigital.ipb.pt/bitstreams/364c4f99-0499-48ac-97da-02b7007141b1/download |
| id | ipb_cd201df4e4cbb4b4953de9d0ca6bfb90 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10198/1553 |
| instacron_str | ipb |
| institution | Instituto Politécnico de Bragança |
| instname_str | Instituto Politécnico de Bragança |
| language | eng |
| network_acronym_str | ipb |
| network_name_str | Biblioteca Digital do IPB |
| oai_identifier_str | oai:bibliotecadigital.ipb.pt:10198/1553 |
| organization_str_mv | urn:organizationAcronym:ipb |
| person_str_mv | Ishikawa, Takuji Fujiwara, Hiroki Matsuki, Noriaki Lima, Rui A. Lima, Rui A. https://www.ciencia-id.pt/EE12-C3FB-349D EE12-C3FB-349D http://orcid.org/0000-0003-3428-637X 0000-0003-3428-637X Imai, Yohsuke Ueno, H. Yamaguchi, Takami |
| publishDate | 2009 |
| publisher.none.fl_str_mv | ASME |
| reponame_str | Biblioteca Digital do IPB |
| repository_id_str | urn:repositoryAcronym:ipb |
| service_str_mv | urn:repositoryAcronym:ipb |
| spelling | engASMEptBlood flow in a microchannel with complex geometries has been investigated to develop biomedical microdevices (e.g. Faivre et al., 2006) or to understand pathology in small vessels, such as lacunar infarcts. In a small channel, say 100 μm in diameter, the blood is no longer assumed to be a homogeneous fluid because the size of the red blood cells (RBCs) cannot be neglected compared to the generated flow field (the diameter of a RBC is about 8 μm). In such a case, we must treat the blood as a multiphase fluid, and investigate the motion of individual cells in discussing the flow field. In this study, we investigated the motion of RBCs in a microchannel with stenosis or bifurcation using a confocal micro-PTV system. We measured individual trajectories of RBCs under high Hct conditions (up to 20%), when the interactions between RBCs become significant. We discuss the effect of Hct on the flow field and cell-free layers, as well as the effect of deformability of RBCs on the cell-free layer thickness by hardening RBCs using a glutaraldehyde treatment.application/pdfptIndividual motions of red blood cells in high-hematocrit blood flowing in a microchannel with complex geometriesIshikawa, TakujiFujiwara, HirokiMatsuki, NoriakiPersonalLima, Rui A.DSpacehttp://dspace.org/items/7b50c499-8095-4f4f-8b1b-fa7388e4ff62DSpacehttp://dspace.org/items/7b50c499-8095-4f4f-8b1b-fa7388e4ff62LimaRui A.Ciência IDhttps://www.ciencia-id.ptEE12-C3FB-349DORCIDhttp://orcid.org0000-0003-3428-637XResearcher IDhttps://www.researcherid.comH-5157-2016Scopus Author IDhttps://www.scopus.com18437397800Imai, YohsukeUeno, H.Yamaguchi, TakamiHostingInstitutionOrganizationalBiblioteca Digital do IPBe-mailmailto:dspace@ipb.ptdspace@ipb.pt2010-01-27T20:11:23Z20092009-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/1553http://purl.org/coar/access_right/c_abf2open accessRed blood cellMicrocirculation1043806 bytesother research producthttp://purl.org/coar/resource_type/c_5794conference paperhttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.ipb.pt/bitstreams/364c4f99-0499-48ac-97da-02b7007141b1/downloadProceeding of the ASME 2009 (SBC2009)Orlando, USA |
| spellingShingle | Individual motions of red blood cells in high-hematocrit blood flowing in a microchannel with complex geometries Ishikawa, Takuji Red blood cell Microcirculation |
| subject.fl_str_mv | Red blood cell Microcirculation |
| title | Individual motions of red blood cells in high-hematocrit blood flowing in a microchannel with complex geometries |
| title_full | Individual motions of red blood cells in high-hematocrit blood flowing in a microchannel with complex geometries |
| title_fullStr | Individual motions of red blood cells in high-hematocrit blood flowing in a microchannel with complex geometries |
| title_full_unstemmed | Individual motions of red blood cells in high-hematocrit blood flowing in a microchannel with complex geometries |
| title_short | Individual motions of red blood cells in high-hematocrit blood flowing in a microchannel with complex geometries |
| title_sort | Individual motions of red blood cells in high-hematocrit blood flowing in a microchannel with complex geometries |
| topic | Red blood cell Microcirculation |
| topic_facet | Red blood cell Microcirculation |
| url | http://hdl.handle.net/10198/1553 |
| visible | 1 |