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Synthesis of aminodiarylamines in the thieno[3,2-b]pyridine series and effects on tumor cell growth inhibition, cell cycle and apoptosis

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Detalhes bibliográficos
Resumo:Several series of compounds that include the thienopyridine scaffold have been reported as inhibitors of known cancer therapeutic targets or as inhibitors of cell proliferation in tumor cell lines [1,2]. Our research group has already synthesized several thieno[3,2-b]pyridine derivatives by Pd-catalyzed C-C (Suzuki and Sonogashira) and C-N (Buchwald-Hartwig) couplings and some of them have presented tumor cell growth inhibitory activity in cell lines [3- 5].
Autores principais:Calhelha, Ricardo C.
Outros Autores:Ferreira, Isabel C.F.R.; Abreu, Rui M.V.; Vale-Silva, Luís A.; Pinto, Eugénia; Lima, Raquel T.; Alvelos, M. Inês; Vasconcelos, M. Helena; Queiroz, Maria João R.P.
Ano:2011
País:Portugal
Tipo de documento:documento de conferência
Tipo de acesso:acesso aberto
Instituição associada:Instituto Politécnico de Bragança
Idioma:inglês
Origem:Biblioteca Digital do IPB
Descrição
Resumo:Several series of compounds that include the thienopyridine scaffold have been reported as inhibitors of known cancer therapeutic targets or as inhibitors of cell proliferation in tumor cell lines [1,2]. Our research group has already synthesized several thieno[3,2-b]pyridine derivatives by Pd-catalyzed C-C (Suzuki and Sonogashira) and C-N (Buchwald-Hartwig) couplings and some of them have presented tumor cell growth inhibitory activity in cell lines [3- 5].